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Cellosaurus KPB-M15 (CVCL_5308)

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Cell line name KPB-M15
Accession CVCL_5308
Resource Identification Initiative To cite this cell line use: KPB-M15 (RRID:CVCL_5308)
Comments Problematic cell line: Contaminated. Shown to be a KYO-1 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 39 year old male patient with chronic myelogenous leukemia, BCR-ABL1 positive.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00230.
Population: Japanese.
Doubling time: 24 hours (PubMed=3461189).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2095 (KYO-1)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=KPB-M15
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=3461189; DOI=10.1093/oxfordjournals.jjco.a039125
Takayuki Kamamoto, Tadashi Ohkubo, Hiroto Sakoda, Yoshio Taniguchi, Kenkichi Kita, Yataro Yoshida, Haruto Uchino;
Establishment of two Ph1 chromosome-positive cell lines, KPB-M8 and KPB-M15.
Jpn. J. Clin. Oncol. 16:107-115(1986)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5308
Biological sample resources BioSample; SAMN03151821
Encyclopedic resources Wikidata; Q54900427
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26