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Cellosaurus OPM-1 (CVCL_5210)

[Text version]
Cell line name OPM-1
Synonyms OPM1
Accession CVCL_5210
Resource Identification Initiative To cite this cell line use: OPM-1 (RRID:CVCL_5210)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Characteristics: Produces Ig lambda.
Doubling time: 36-42 hours (PubMed=3926660).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (DepMap=ACH-000057).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Lys650Glu (c.1948A>G); ClinVar=VCV000016331; Zygosity=Heterozygous (PubMed=11157491; DepMap=ACH-000057).
  • Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Leu87Arg (c.260T>G); Zygosity=Heterozygous (DepMap=ACH-000057).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (DepMap=ACH-000057).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.52
Native American0
East Asian, North74.49
East Asian, South22.3
South Asian0
European, North0
European, South2.68
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1625 ! OPM-2
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): Technion Genomics Center

Markers:
AmelogeninX
CSF1PO12,13
D1S165616,17.3
D2S44110
D2S133819,25
D3S135815,18
D5S81813
D7S82012
D8S117910,13
D10S124814
D12S39117,18
D13S31711
D16S5399,13
D18S5113,14,15
D19S43314,14.2
D21S1130,33.2
D22S104511,17
FGA20,21
Penta D9
Penta E12,20,21
TH016,7
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=3926660; DOI=10.1002/ijc.2910360217
Shuichi Katagiri, Takeshi Yonezawa, Jun Kuyama, Yoshio Kanayama, Kazuhiro Nishida, Tatsuo Abe, Toshiharu Tamaki, Mitsunobu Ohnishi, Seiichiro Tarui;
Two distinct human myeloma cell lines originating from one patient with myeloma.
Int. J. Cancer 36:241-246(1985)

PubMed=10087940; DOI=10.1016/S0165-4608(98)00157-5
Jeroen Kuipers, Jan Willem Vaandrager, Danielle Olde Weghuis, Peter Lees Pearson, Jacques Scheres, Henk Martinus Lokhorst, Hans Cornelius Clevers, Bert J.E.G. Bast;
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
Cancer Genet. Cytogenet. 109:99-107(1999)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11157491; DOI=10.1182/blood.V97.3.729
Marta Chesi, Leslie A. Brents, Sarah A. Ely, Carlos Bais, Davide F. Robbiani, Enrique A. Mesri, Walter Michael Kuehl, Peter Leif Bergsagel;
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Jonathan J. Keats, Rafael Fonseca, Marta Chesi, Roelandt Schop, Angela Baker, Wee-Joo Chng, Scott Van Wier, Rodger Tiedemann, Chang-Xin Shi, Michael Sebag, Esteban Braggio ...Show all 30 authors... , Travis Henry, Yuan-Xiao Zhu, Homer Fogle, Tammy L. Price-Troska, Gregory J. Ahmann, Catherine Mancini, Leslie A. Brents, Shaji K. Kumar, Philip Robert Greipp, Angela Dispenzieri, Barb Bryant, George Mulligan, Laurakay Bruhn, Michael T. Barrett, Riccardo Valdez, Jeffrey M. Trent, A. Keith Stewart, John D. Carpten, Peter Leif Bergsagel; Show fewer authors
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Amel Dib, Ana Gabrea, Oleg K. Glebov, Peter Leif Bergsagel, Walter Michael Kuehl;
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5210
Cell_Model_Passport; SIDM00456
DepMap; ACH-000057
Lonza; 28
Biological sample resources BioSample; SAMN10989618
Encyclopedic resources Wikidata; Q54936481
Polymorphism and mutation databases Cosmic; 720768
Cosmic; 2081431
Cosmic; 2367299
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number29