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Cellosaurus K562/Vin (CVCL_5145)

[Text version]
Cell line name K562/Vin
Synonyms K562/VCR; K562 H-1; H-1
Accession CVCL_5145
Resource Identification Initiative To cite this cell line use: K562/Vin (RRID:CVCL_5145)
Comments Population: Caucasian.
Doubling time: 24.1 +- 1.8 hours (PubMed=6580255).
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2111; TKG=TKG 0212

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8209,11
D13S3178
D16S53911,12
TH019.3
TPOX8,9
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=6580255; DOI=10.20772/cancersci1959.74.5_751
Tsuruo T., Iida H., Ohkochi E., Tsukagoshi S., Sakurai Y.
Establishment and properties of vincristine-resistant human myelogenous leukemia K562.
Gann 74:751-758(1983)

PubMed=6684716; DOI=10.1016/0145-2126(83)90043-7
Okabe-Kado J., Hayashi M., Honma Y., Hozumi M., Tsuruo T.
Effects of inducers of erythroid differentiation of human leukemia K562 cells on vincristine-resistant K562/VCR cells.
Leuk. Res. 7:481-485(1983)

Cross-references
Cell line collections (Providers) RCB; RCB2111
TKG; TKG 0212
Cell line databases/resources CLO; CLO_0050125
Chemistry resources ChEMBL-Cells; CHEMBL4295433
ChEMBL-Targets; CHEMBL4296450
PubChem_Cell_line; CVCL_5145
Encyclopedic resources Wikidata; Q54899418
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24