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Cellosaurus K562/MTX-2 (CVCL_5144)

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Cell line name K562/MTX-2
Accession CVCL_5144
Resource Identification Initiative To cite this cell line use: K562/MTX-2 (RRID:CVCL_5144)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): RCB=RCB0474

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8209,11
D13S3178
D16S53911,12
TH016,9.3
TPOX8,9
vWA16

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Publications

PubMed=2465288; DOI=10.1111/j.1349-7006.1988.tb01549.x; PMCID=PMC5917644
Shoichi Koizumi;
Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines.
Jpn. J. Cancer Res. 79:1230-1237(1988)

Cross-references
Cell line collections (Providers) RCB; RCB0474
Cell line databases/resources CLO; CLO_0050119
Biological sample resources BioSample; SAMN03472320
Encyclopedic resources Wikidata; Q54899414
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24