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Cellosaurus HCC2429 (CVCL_5132)

[Text version]
Cell line name HCC2429
Synonyms HCC-2429; Hamon Cancer Center 2429
Accession CVCL_5132
Resource Identification Initiative To cite this cell line use: HCC2429 (RRID:CVCL_5132)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: HCC-2425; PubMed=29348827; Note=In table of supplementary material.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
Disease Lung non-small cell carcinoma (NCIt: C2926)
NUT carcinoma (NCIt: C45716)
NUT midline carcinoma (ORDO: Orphanet_443167)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_V989 ! HCC2429 BL
Sex of cell Female
Age at sampling 34Y
Category Cancer cell line
STR profile Source(s): PubMed=20679594

Markers:
AmelogeninX
CSF1PO10,13
D5S81812,14
D7S82010,11
D13S31711
D16S53911,13
TH016,9
TPOX8
vWA16

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; VCCTC; MKT11126; https://vanderbilt.technologypublisher.com/technology/12194
Publications

PubMed=10944559; DOI=10.1093/jnci/92.16.1355
Thao Phuong Dang, Adi F. Gazdar, Arvind K. Virmani, Tanya Sepetavec, Kenneth R. Hande, John D. Minna, John R. Roberts, David P. Carbone;
Chromosome 19 translocation, overexpression of Notch3, and human lung cancer.
J. Natl. Cancer Inst. 92:1355-1357(2000)

PubMed=15994877; DOI=10.1136/jmg.2004.029686; PMCID=PMC1736105
Nobuhiro Haruki, Keiko S. Kawaguchi, Shannon Eichenberger, Pierre Pascal Massion, Adrian Gonzalez, Adi F. Gazdar, John D. Minna, David P. Carbone, Thao Phuong Dang;
Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro.
J. Med. Genet. 42:558-564(2005)

PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474
Adi F. Gazdar, Luc Girard, William W. Lockwood, Wan L. Lam, John D. Minna;
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658; PMCID=PMC4097982
Ran-Ran Wang, Wei Liu, Christine M. Helfer, James E. Bradner, Jason L. Hornick, Susan M. Janicki, Christopher Alexander French, Jian-Xin You;
Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma.
Cancer Res. 74:3332-3343(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512
Anja Stirnweiss, Joyce Oommen, Rishi S. Kotecha, Ursula R. Kees, Alex H. Beesley;
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Oncotarget 8:112313-112329(2017)

PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540
Elizabeth A. McMillan, Myung-Jeom Ryu, Caroline H. Diep, Saurabh Mendiratta, Jean Rene Clemenceau, Rachel M. Vaden, Ju-Hwa Kim, Takashi Motoyaji, Kyle R. Covington, Michael Peyton, Kenneth Huffman ...Show all 40 authors... , Xiao-Feng Wu, Luc Girard, Yeojin Sung, Pei-Hsaun Chen, Prema Latha Mallipeddi, Joo Young Lee, Jordan Hanson, Sukesh Voruganti, Yunku Yu, Sunho Park, Jessica Sudderth, Christopher DeSevo, Donna M. Muzny, HarshaVardhan Doddapaneni, Adi F. Gazdar, Richard Alexander Gibbs, Tae Hyun Hwang, John Victor Heymach, Ignacio Ivan Wistuba, Kevin Robert Coombes, Noelle S. Williams, David A. Wheeler, John B. MacMillan, Ralph J. DeBerardinis, Michael G. Roth, Bruce Arthur Posner, John D. Minna, Hyun Seok Kim, Michael A. White; Show fewer authors
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
James L. Mulshine, Peter Ujhazy, Melissa Antman, Christine M. Burgess, Igor A. Kuzmin, Paul A. Bunn Jr., Bruce E. Johnson, Jack Alan Roth, Harvey I. Pass, Sheila M. Ross, Carolyn R. Aldige ...Show all 13 authors... , Ignacio Ivan Wistuba, John D. Minna; Show fewer authors
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5132
Cell_Model_Passport; SIDM01601
DepMap; ACH-000143
IGRhCellID; HCC2429GEO
Biological sample resources BioSample; SAMN10989601
Encyclopedic resources Wikidata; Q54881655
Experimental variables resources EFO; EFO_0022526
Gene expression databases GEO; GSM171900
GEO; GSM171901
GEO; GSM253412
GEO; GSM434319
GEO; GSM794394
GEO; GSM817123
Polymorphism and mutation databases Cosmic; 903644
Cosmic; 1146931
Cosmic; 1340147
Cosmic; 1518099
Progenetix; CVCL_5132
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number27