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Cellosaurus ACC-MESO-4 (CVCL_5114)

[Text version]
Cell line name ACC-MESO-4
Synonyms ACC-Meso-4; MESO-4
Accession CVCL_5114
Resource Identification Initiative To cite this cell line use: ACC-MESO-4 (RRID:CVCL_5114)
Comments Population: Japanese.
Transformant: ChEBI; CHEBI_46661; Asbestos.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=16630136).
  • Mutation; HGNC; HGNC:950; BAP1; Simple; p.Tyr724Ter (c.2172delC); Zygosity=Unspecified (PubMed=26011428).
  • Mutation; HGNC; HGNC:20796; RASSF6; Simple; p.Arg155fs (c.464_465insA); Zygosity=Unspecified (PubMed=25902174).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2293

Markers:
AmelogeninX,Y
CSF1PO12
D5S8189,11
D7S82012,14
D13S3178,11
D16S5399,10
TH017,8
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=16630136; DOI=10.1111/j.1349-7006.2006.00184.x; PMCID=PMC11158456
Noriyasu Usami, Takayuki Fukui, Masashi Kondo, Tetsuo Taniguchi, Toshihiko Yokoyama, Shoichi Mori, Kohei Yokoi, Yoshitsugu Horio, Kaoru Shimokata, Yoshitaka Sekido, Toyoaki Hida;
Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.
Cancer Sci. 97:387-394(2006)

PubMed=17270034; DOI=10.1111/j.1349-7006.2006.00386.x; PMCID=PMC11158069
Tetsuo Taniguchi, Sivasundaram Karnan, Takayuki Fukui, Toshihiko Yokoyama, Hiroyuki Tagawa, Kohei Yokoi, Yuichi Ueda, Tetsuya Mitsudomi, Yoshitsugu Horio, Toyoaki Hida, Yasushi Yatabe ...Show all 13 authors... , Masao Seto, Yoshitaka Sekido; Show fewer authors
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Cancer Sci. 98:438-446(2007)

PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164
Hideki Murakami, Tetsuya Mizuno, Tetsuo Taniguchi, Makiko Fujii, Futoshi Ishiguro, Takayuki Fukui, Shinya Akatsuka, Yoshitsugu Horio, Toyoaki Hida, Yutaka Kondo, Shinya Toyokuni ...Show all 13 authors... , Hirotaka Osada, Yoshitaka Sekido; Show fewer authors
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Cancer Res. 71:873-883(2011)

PubMed=25902174; DOI=10.1097/JTO.0000000000000493
Akihiko Miyanaga, Mari Masuda, Koji Tsuta, Kumiko Kawasaki, Yuka Nakamura, Tomohiro Sakuma, Hisao Asamura, Akihiko Gemma, Tesshi Yamada;
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
J. Thorac. Oncol. 10:844-851(2015)

PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387
Shuhei Hakiri, Hirotaka Osada, Futoshi Ishiguro, Hideki Murakami, Yuko Murakami-Tonami, Kohei Yokoi, Yoshitaka Sekido;
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
T. Kato, Tatsuhiro Sato, Kohei Yokoi, Yoshitaka Sekido;
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

Cross-references
Cell line collections (Providers) RCB; RCB2293
Cell line databases/resources CLO; CLO_0050083
cancercelllines; CVCL_5114
Biological sample resources BioSample; SAMN03471959
Encyclopedic resources Wikidata; Q54608246
Gene expression databases FANTOM5_SSTAR; 10494-107B8
GEO; GSM551968
GEO; GSM850297
Polymorphism and mutation databases Cosmic; 877274
Cosmic; 1481541
Cosmic; 2759003
Cosmic; 2759232
IARC_TP53; 24549
Progenetix; CVCL_5114
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number23