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Cellosaurus SNU-685 (CVCL_5083)

[Text version]
Cell line name SNU-685
Synonyms SNU685; NCI-SNU-685
Accession CVCL_5083
Resource Identification Initiative To cite this cell line use: SNU-685 (RRID:CVCL_5083)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 20 hours (PubMed=9299262).
Omics: Genomics; Chromatin accessibility; ATAC-seq.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.919+1G>T (IVS8+1G>T); ClinVar=VCV000495326; Zygosity=Homozygous; Note=Splice donor mutation (DepMap=ACH-000407).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,33:03
HLA-BB*44:02,54:01
HLA-CC*14:03,14:03
Class II
HLA-DQDQA1*04:01,04:01
DQB1*03:23,03:23
HLA-DRDRB1*04:03,13:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.15
Native American0.59
East Asian, North63.21
East Asian, South35.03
South Asian0
European, North0
European, South0.02
Disease Uterine carcinosarcoma (NCIt: C42700)
Carcinosarcoma of the corpus uteri (ORDO: Orphanet_213610)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): KCLB=00685

Markers:
AmelogeninX
CSF1PO11
D3S135814
D5S81812
D7S8208,12
D13S3178
FGA21
TH016,9.3
TPOX9
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=9299262; DOI=10.1006/gyno.1997.4802
Ying Yuan, Woo-Ho Kim, Hye Seung Han, Jae-Ho Lee, Hyun-Sook Park, June-Key Chung, Soon-Beom Kang, Jae-Gahb Park;
Establishment and characterization of cell lines derived from uterine malignant mixed Mullerian tumor.
Gynecol. Oncol. 66:464-474(1997)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416
Ja-Lok Ku, Jae-Gahb Park;
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers) KCLB; 00685
Cell line databases/resources cancercelllines; CVCL_5083
Cell_Model_Passport; SIDM00165
DepMap; ACH-000407
Biological sample resources BioSample; SAMN10988056
CRISP screens repositories BioGRID_ORCS_Cell_line; 697
Chemistry resources PharmacoDB; SNU685_1478_2019
Encyclopedic resources Wikidata; Q54955250
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM888726
GEO; GSM3161726
GEO; GSM3161727
Polymorphism and mutation databases IARC_TP53; 28262
LiGeA; CCLE_719
Progenetix; CVCL_5083
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30