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Cellosaurus SNU-46 (CVCL_5063)

[Text version]
Cell line name SNU-46
Synonyms SNU46
Accession CVCL_5063
Resource Identification Initiative To cite this cell line use: SNU-46 (RRID:CVCL_5063)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 36 hours (PubMed=10369293).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Pro114His (c.341C>A) (p.Ala128Ala, c.384C>A); ClinVar=VCV000376383; Zygosity=Homozygous (PubMed=10369293; DepMap=ACH-000500).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Homozygous (PubMed=10369293; DepMap=ACH-000500).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.74
Native American0
East Asian, North68.94
East Asian, South24.69
South Asian0
European, North0
European, South4.64
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): KCLB=00046

Markers:
AmelogeninX
CSF1PO10,12
D3S135815
D5S81811
D7S82010,11
D13S31711
FGA21,24
TH019
TPOX8,11
vWA15,16

Run an STR similarity search on this cell line
Publications

CLPUB00001
Kwang Hyun Kim, Phil-Sang Chung, Hyun Min Park, Chae-Seo Rhee, Jae-Gahb Park;
Establishment and characterization of cell lines derived from squamous cell carcinoma of the head and neck.
Korean J. Head Neck Oncol. 12:181-187(1996)

PubMed=10369293; DOI=10.1097/00005537-199906000-00025
Ja-Lok Ku, Woo-Ho Kim, Jae-Ho Lee, Hyun-Sook Park, Kwang Hyun Kim, Myung-Whun Sung, Jae-Gahb Park;
Establishment and characterization of human laryngeal squamous cell carcinoma cell lines.
Laryngoscope 109:976-982(1999)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416
Ja-Lok Ku, Jae-Gahb Park;
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) KCLB; 00046
Cell line databases/resources cancercelllines; CVCL_5063
Cell_Model_Passport; SIDM01448
DepMap; ACH-000500
Anatomy/cell type resources BTO; BTO_0005927
Biological sample resources BioSample; SAMN10988080
Chemistry resources PharmacoDB; SNU46_1463_2019
Encyclopedic resources Wikidata; Q54955202
Gene expression databases GEO; GSM887629
GEO; GSM888714
Polymorphism and mutation databases Cosmic; 934173
IARC_TP53; 11322
Progenetix; CVCL_5063
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29