Cell line name |
SNU-1746 |
Synonyms |
SNU1746 |
Accession |
CVCL_5030 |
Resource Identification Initiative |
To cite this cell line use: SNU-1746 (RRID:CVCL_5030) |
Comments |
Part of: Seoul National University (SNU) cell line collection. Population: Korean. Doubling time: 42 hours (PubMed=20176655). Microsatellite instability: Instable (MSI-high) (PubMed=20176655; PubMed=25926053). Omics: Transcriptomics; Microarray. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr562fs*19 (c.1682_1683insA); Zygosity=Heterozygous (PubMed=20176655).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1429Ter (c.4285C>T); ClinVar=VCV000376063; Zygosity=Heterozygous (PubMed=20176655).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (PubMed=20176655).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20176655).
- Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Glu523Lys (c.1567G>A); Zygosity=Homozygous (PubMed=20176655).
- Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=20176655).
|
Disease |
Colon signet ring cell adenocarcinoma (NCIt: C7967) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Sex of cell |
Male |
Age at sampling |
43Y |
Category |
Cancer cell line |
STR profile |
Source(s): KCLB=01746; PubMed=20176655; PubMed=25926053
Markers:Amelogenin | X,Y |
CSF1PO | 7,9 |
D2S1338 | 18,24 |
D3S1358 | 14,17 |
D5S818 | 11,12,13 (KCLB=01746) 11,12,13,14 (PubMed=25926053) 12,13 (PubMed=20176655) |
D7S820 | 8,11 |
D8S1179 | 11 |
D13S317 | 9 |
D16S539 | 9,14 |
D18S51 | 13,18 |
D19S433 | 13,17.2 |
D21S11 | 28,33 |
FGA | 17,22 |
TH01 | 6 |
TPOX | 8,9 |
vWA | 15,18 (KCLB=01746; PubMed=20176655) 18 (PubMed=25926053) |
Run an STR similarity search on this cell line |
Publications | PubMed=20176655; DOI=10.1093/carcin/bgq043 Ja-Lok Ku, Young-Kyoung Shin, Duck-Woo Kim, Kyung-Hee Kim, Jin-Sung Choi, Sung-Hye Hong, You-Kyung Jeon, Sung-Hee Kim, Hong-Sun Kim, Jae-Hyun Park, Il-Jin Kim, Jae-Gahb Park; Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. Carcinogenesis 31:1003-1009(2010) PubMed=25926053; DOI=10.1038/ncomms8002 Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. Nat. Commun. 6:7002.1-7002.10(2015) |
Cross-references |
Cell line collections (Providers) |
KCLB; 01746
|
Cell line databases/resources |
cancercelllines; CVCL_5030
ColonAtlas; SNU1746
|
Encyclopedic resources |
Wikidata; Q54955128
|
Gene expression databases |
GEO; GSM1448206
|
Polymorphism and mutation databases |
Cosmic; 1322294
IARC_TP53; 28483
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 10-Apr-2025 |
Version number | 26 |
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