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Cellosaurus MDA-MB-231DR (CVCL_4Z65)

[Text version]
Cell line name MDA-MB-231DR
Accession CVCL_4Z65
Resource Identification Initiative To cite this cell line use: MDA-MB-231DR (RRID:CVCL_4Z65)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=16928833; DOI=10.1158/1535-7163.MCT-06-0190
Smith L., Watson M.B., O'Kane S.L., Drew P.J., Lind M.J., Cawkwell L.
The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays.
Mol. Cancer Ther. 5:2115-2120(2006)

Cell line databases/resources cancercelllines; CVCL_4Z65
Encyclopedic resources Wikidata; Q54904619
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number17