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Cellosaurus HEL/TGR (CVCL_4Z61)

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Cell line name HEL/TGR
Accession CVCL_4Z61
Resource Identification Initiative To cite this cell line use: HEL/TGR (RRID:CVCL_4Z61)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90304; TG101209 (N-(tert-butyl)-3-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide).
Donor information: Originally the patient was suffering from Hodgkin lymphoma.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Lys (c.398T>A); ClinVar=VCV002430159; Zygosity=Homozygous (from parent cell line).
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2481 (HEL 92.1.7)
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=21976548; DOI=10.1158/1078-0432.CCR-11-1541; PMCID=PMC3743080
Warren Fiskus, Srdan Verstovsek, Taghi Manshouri, Rekha Rao, Ramesh Balusu, Sreedhar Venkannagari, Narasimharao Nalabothula, Kyungsoo Ha, Jacqueline E. Smith, Stacey L. Hembruff, Sunil Abhyankar ...Show all 13 authors... , Joseph Patrick McGuirk, Kapil N. Bhalla; Show fewer authors
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
Clin. Cancer Res. 17:7347-7358(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Z61
Encyclopedic resources Wikidata; Q54882508
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number12