Cellosaurus cell line TC-4C (CVCL

Cellosaurus TC-4C (CVCL_4Z37)

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Cell line name

TC-4C

Accession

CVCL_4Z37

Resource Identification Initiative

To cite this cell line use: TC-4C (RRID:CVCL_4Z37)

Comments

Omics: Transcriptomics; RNAseq.

Sequence variations

Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG (PubMed=25010205).
Mutation; HGNC; HGNC:11355; STAG2; Unexplicit; Ex5-12del; Zygosity=Hemizygous (PubMed=25010205).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Arg (c.581T>G); ClinVar=VCV000376633; Zygosity=Unspecified (PubMed=25010205).

Disease

Ewing sarcoma/peripheral primitive neuroectodermal tumor (NCIt: C27291)
Bone sarcoma (ORDO: Orphanet_223727)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Category

Cancer cell line

STR profile

Source(s): PubMed=25010205

Markers:

Amelogenin	X,Y
CSF1PO	11
D2S1338	19,26
D3S1358	16
D5S818	10
D7S820	11
D8S1179	12
D13S317	13
D16S539	9,11
D18S51	12,17
D19S433	14,16.2
D21S11	29
FGA	20,22
TH01	9.3
TPOX	8
vWA	15,18

Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez-Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_4Z37

Encyclopedic resources

Wikidata; Q54971814

Polymorphism and mutation databases

Cosmic; 2228245

Entry history

Entry creation

14-Dec-2015

Last entry update

10-Apr-2025

Version number