Cellosaurus cell line TC-248 (CVCL

Cellosaurus TC-248 (CVCL_4Z35)

[Text version]

Cell line name

TC-248

Synonyms

TC248

Accession

CVCL_4Z35

Resource Identification Initiative

To cite this cell line use: TC-248 (RRID:CVCL_4Z35)

Comments

Part of: MD Anderson Cell Lines Project.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=25010205).
Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=25010205).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp259Tyr (c.775G>T); ClinVar=VCV000634680; Zygosity=Unspecified (PubMed=25010205).

Disease

Ewing sarcoma/peripheral primitive neuroectodermal tumor (NCIt: C27291)
Bone sarcoma (ORDO: Orphanet_223727)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Category

Cancer cell line

STR profile

Source(s): PubMed=25010205

Markers:

Amelogenin	X
CSF1PO	10,11
D2S1338	17
D3S1358	15
D5S818	12,13
D7S820	8,10
D8S1179	10,14
D13S317	11
D16S539	9,12
D18S51	16,17
D19S433	14,15
D21S11	29,30
FGA	19,20.2
TH01	7,8
TPOX	11
vWA	17,18

Web pages

Info; MCLP; -; https://tcpaportal.org/mclp/

Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_4Z35

Encyclopedic resources

Wikidata; Q54971804

Polymorphism and mutation databases

Cosmic; 2228241

Entry history

Entry creation

14-Dec-2015

Last entry update

10-Apr-2025

Version number