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Cellosaurus TC-240 (CVCL_4Z33)

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Cell line name TC-240
Accession CVCL_4Z33
Resource Identification Initiative To cite this cell line use: TC-240 (RRID:CVCL_4Z33)
Comments Omics: Transcriptomics; RNAseq.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 3 fusion (Ex10/Ex6) (PubMed=25010205).
  • Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Arg216Ter (c.646C>T); Zygosity=Unspecified (PubMed=25010205).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=25010205).
Disease Ewing sarcoma/peripheral primitive neuroectodermal tumor (NCIt: C27291)
Bone sarcoma (ORDO: Orphanet_223727)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133820,24
D3S135818
D5S81811,13
D7S8209,12
D8S117913,14
D13S31712
D16S53911,12
D18S5113,14
D19S43314,15
D21S1129,30
FGA23
TH018,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez-Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Z33
Encyclopedic resources Wikidata; Q54971802
Polymorphism and mutation databases Cosmic; 2228239
Entry history
Entry creation14-Dec-2015
Last entry update10-Apr-2025
Version number12