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Cellosaurus TC-138 (CVCL_4Z30)

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Cell line name TC-138
Synonyms TC138
Accession CVCL_4Z30
Resource Identification Initiative To cite this cell line use: TC-138 (RRID:CVCL_4Z30)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=25010205).
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 4 fusion (Ex10/Ex5) (PubMed=25010205).
Disease Ewing sarcoma/peripheral primitive neuroectodermal tumor (NCIt: C27291)
Bone sarcoma (ORDO: Orphanet_223727)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,23
D3S135816,18
D5S81812
D7S8209,11
D8S117910
D13S3178,10
D16S53910
D18S5113,14
D19S43313,14
D21S1129
FGA22
TH017,9
TPOX11
vWA19

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/tables/Ewings.php
Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez-Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM01467
DepMap; ACH-001430
Encyclopedic resources Wikidata; Q54971795
Polymorphism and mutation databases Cosmic; 2228236
Entry history
Entry creation14-Dec-2015
Last entry update10-Apr-2025
Version number12