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Cellosaurus MVLN (CVCL_4Y56)

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Cell line name MVLN
Synonyms MVLN 15-C7; MVLN-15-C7; MCF-7 Vit Luc Neo
Accession CVCL_4Y56
Resource Identification Initiative To cite this cell line use: MVLN (RRID:CVCL_4Y56)
Comments Population: Caucasian.
Biotechnology: Used in a bioluminescent bioassay to quantitatively measure estrogenic compounds.
Characteristics: The luciferase reporter gene is under the control of an estrogen-responsive element from the Xenopus vitellogenin A2 gene.
Doubling time: 0.8 +- 0.1 day (PubMed=7954415).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=2257144
Michel Pons, Didier Gagne, Jean-Claude Nicolas, Majid Mehtali;
A new cellular model of response to estrogens: a bioluminescent test to characterize (anti) estrogen molecules.
BioTechniques 9:450-459(1990)

PubMed=9831484; DOI=10.1016/0960-0760(93)90225-L
Ediz Demirpence, Marie-Josephe Duchesne, Eric Badia, Didier Gagne, Michel Pons;
MVLN cells: a bioluminescent MCF-7-derived cell line to study the modulation of estrogenic activity.
J. Steroid Biochem. Mol. Biol. 46:355-364(1993)

PubMed=7954415
Eric Badia, Marie-Josephe Duchesne, Sylvie Fournier-Bidoz, Anne-Emmanuelle Simar-Blanchet, Beatrice Terouanne, Jean-Claude Nicolas, Michel Pons;
Hydroxytamoxifen induces a rapid and irreversible inactivation of an estrogenic response in an MCF-7-derived cell line.
Cancer Res. 54:5860-5866(1994)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Y56
Chemistry resources ChEMBL-Cells; CHEMBL3307321
ChEMBL-Targets; CHEMBL614185
PubChem_Cell_line; CVCL_4Y56
Encyclopedic resources Wikidata; Q54907119
Entry history
Entry creation14-Dec-2015
Last entry update14-Aug-2025
Version number19