| Cell line name |
MDA-MB-231 25PACR |
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| Accession |
CVCL_4Y38 |
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| Resource Identification Initiative |
To cite this cell line use: MDA-MB-231 25PACR (RRID:CVCL_4Y38) |
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| Comments |
Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
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| Disease |
Breast adenocarcinoma (NCIt: C5214) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231) |
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| Sex of cell |
Female |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25312014; DOI=10.1186/1471-2407-14-762
Kenicer J., Spears M., Lyttle N., Taylor K.J., Liao L., Cunningham C.A., Lambros M.B., MacKay A., Yao C., Reis-Filho J.S., Bartlett J.M.S.
Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.
BMC Cancer 14:762.1-762.10(2014) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54904580
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 29-Jun-2023 |
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| Version number | 16 |
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