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Cellosaurus POLK KO homo MSH- (CVCL_4W73)

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Cell line name POLK KO homo MSH-
Synonyms Nalm-6-MSH-/TK+/-/POLK-/-
Accession CVCL_4W73
Resource Identification Initiative To cite this cell line use: POLK KO homo MSH- (RRID:CVCL_4W73)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:9183; POLK.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:11830; TK1 (Note=1 of 2 alleles).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UD96 (Nalm-6-TK+/-)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1514

Markers:
AmelogeninX,Y
CSF1PO14
D5S81811,12
D7S8208,12
D13S3179,13
D16S53910,11
TH018,9
TPOX8,10
vWA15,16

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Publications

PubMed=24461735; DOI=10.1016/j.dnarep.2013.12.008
Akira Sassa, Tetsuya Suzuki, Yuki Kanemaru, Naoko Niimi, Hirofumi Fujimoto, Atsushi Katafuchi, Petr Gruz, Manabu Yasui, Ramesh C. Gupta, Francis Johnson, Toshihiro Ohta ...Show all 14 authors... , Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi; Show fewer authors
In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa.
DNA Repair 15:21-28(2014)

Cross-references
Cell line collections (Providers) JCRB; JCRB1514
Cell line databases/resources cancercelllines; CVCL_4W73
Encyclopedic resources Wikidata; Q54947730
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number16