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Cellosaurus SKOV-3TR (CVCL_4V89)

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Cell line name SKOV-3TR
Accession CVCL_4V89
Resource Identification Initiative To cite this cell line use: SKOV-3TR (RRID:CVCL_4V89)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=10095106; DOI=10.1016/S0378-1119(99)00042-6
Zhen-Feng Duan, Aynn J. Feller, Han Chong Toh, Thomas Makastorsis, Michael V. Seiden;
TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line.
Gene 229:75-81(1999)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V89
Encyclopedic resources Wikidata; Q54954765
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number16