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Cellosaurus K562/AS2 (CVCL_4V85)

[Text version]
Cell line name K562/AS2
Accession CVCL_4V85
Resource Identification Initiative To cite this cell line use: K562/AS2 (RRID:CVCL_4V85)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_30621; Diarsenic trioxide (ATO; As2O3).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

CLPUB00269
Jia-Cai Zhuo, Ming-Chun Wang, Xiao-Mei Tao, Ming Li, Li-Ping Nie, Qiong-Li Zhang, Dun-Yun Shi;
Establishment of arsenic trioxide-resistant K562/AS2 cell line and the mechanism of multidrug resistance.
Chin. J. Pathophysiol. 18:840-843(2002)

Cross-references
Encyclopedic resources Wikidata; Q54899406
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number16