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Cellosaurus OPM-2/BTZ (CVCL_4V72)

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Cell line name OPM-2/BTZ
Synonyms OPM2/BTZ
Accession CVCL_4V72
Resource Identification Initiative To cite this cell line use: OPM-2/BTZ (RRID:CVCL_4V72)
Comments Population: Japanese.
Characteristics: Produces Ig lambda.
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Lys650Glu (c.1948A>G); ClinVar=VCV000016331; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Leu87Arg (c.260T>G); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1625 (OPM-2)
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=20555361; DOI=10.1038/leu.2010.137
Masaki Ri, Shinsuke Iida, Takayuki Nakashima, Hideyuki Miyazaki, Fumiko Mori, Asahi Ito, Atsushi Inagaki, Shigeru Kusumoto, Takashi Ishida, Hirokazu Komatsu, Yukimasa Shiotsu, Ryuzo Ueda;
Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress.
Leukemia 24:1506-1512(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V72
Encyclopedic resources Wikidata; Q54936484
Entry history
Entry creation14-Dec-2015
Last entry update14-Aug-2025
Version number15