Cellosaurus cell line MCF7-AFA[r] (CVCL

Cross-references
Cell line name	MCF7-AFA[r]
Accession	CVCL_4V66
Resource Identification Initiative	To cite this cell line use: MCF7-AFA[r] (RRID:CVCL_4V66)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_61390; Afatinib (BIBW-2992). Miscellaneous: Cell line is no longer available (personal communication of Dowding, Charles). Discontinued: ChemoScreen; Catalog number 10041C. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Cell line databases/resources	cancercelllines; CVCL_4V66
Encyclopedic resources	Wikidata; Q54904462
Entry history
Entry creation	14-Dec-2015
Last entry update	10-Apr-2025
Version number	15