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Cellosaurus LoVo/irinotecan (CVCL_4V50)

[Text version]
Cell line name LoVo/irinotecan
Accession CVCL_4V50
Resource Identification Initiative To cite this cell line use: LoVo/irinotecan (RRID:CVCL_4V50)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:80630; Irinotecan (Camptothecin-11; CPT-11).
Omics: Proteome analysis by 2D-DE/MS.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0399 (LoVo)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=21289438; DOI=10.1007/s12038-010-0064-9
Peng X.-C., Gong F.-M., Wei M., Chen X., Chen Y., Cheng K., Gao F., Xu F., Bi F., Liu J.-Y.
Proteomic analysis of cell lines to identify the irinotecan resistance proteins.
J. Biosci. 35:557-564(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V50
Encyclopedic resources Wikidata; Q54902905
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number15