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Cellosaurus KCL22/SR (CVCL_4V46)

[Text version]
Cell line name KCL22/SR
Accession CVCL_4V46
Resource Identification Initiative To cite this cell line use: KCL22/SR (RRID:CVCL_4V46)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Leufs*5 (c.3261dupC) (3261_3262insC); ClinVar=VCV000089364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro301Glnfs*44 (c.902delC); ClinVar=VCV000233908; Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2091 (KCL-22)
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line

PubMed=12743326; DOI=10.1634/stemcells.21-3-315
Ohmine K., Nagai T., Tarumoto T., Miyoshi T., Muroi K., Mano H., Komatsu N., Takaku F., Ozawa K.
Analysis of gene expression profiles in an imatinib-resistant cell line, KCL22/SR.
Stem Cells 21:315-321(2003)

Cell line databases/resources cancercelllines; CVCL_4V46
Encyclopedic resources Wikidata; Q54899694
Entry history
Entry creation14-Dec-2015
Last entry update02-May-2024
Version number12