Cellosaurus cell line MCF-7/5-23 (CVCL

Cellosaurus MCF-7/5-23 (CVCL_4V44)

Cross-references
Cell line name	MCF-7/5-23
Synonyms	MCF 7/5-23; MCF 5-23; 5-23
Accession	CVCL_4V44
Resource Identification Initiative	To cite this cell line use: MCF-7/5-23 (RRID:CVCL_4V44)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Publications	PubMed=8244585; DOI=10.1002/ijc.2910550529 Xiu F. Hu, Marta C. Veroni, Mario de Luise, Alan E. Wakeling, Grant Robert Sutherland, Colin K.W. Watts, John Raymond Zalcberg; Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780. Int. J. Cancer 55:873-876(1993) PubMed=10070856; DOI=10.1038/sj.bjc.6690112; PMCID=PMC2362670 John Phillip Parisot, Xiu F. Hu, Mario de Luise, John Raymond Zalcberg; Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line. Br. J. Cancer 79:693-700(1999)
Cell line databases/resources	cancercelllines; CVCL_4V44
Encyclopedic resources	Wikidata; Q54904349
Entry history
Entry creation	14-Dec-2015
Last entry update	19-Dec-2024
Version number	14