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Cellosaurus AC12 (CVCL_4U17)

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Cell line name AC12
Accession CVCL_4U17
Resource Identification Initiative To cite this cell line use: AC12 (RRID:CVCL_4U17)
Comments Characteristics: Hybrid of adult ventricular cardiomiocytes with a SV40 transformed, uridine auxotroph human fibroblast cell line devoid of mitochondrial DNA (PubMed=15913645).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRNS-1).
Derived from site: In situ; Heart, ventricle; UBERON=UBERON_0002082.
Cell type: Cardiomyocyte; CL=CL_0002495.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4U14 (DWFb1-rho0)
Category Hybrid cell line
Publications

PubMed=15913645; DOI=10.1016/j.yjmcc.2005.03.003
Mercy Mascren Davidson, Claudia Nesti, Lluis Palenzuela, Winsome F. Walker, Evelyn Hernandez, Lev Protas, Michio Hirano, Nithila Doraipandyan Isaac;
Novel cell lines derived from adult human ventricular cardiomyocytes.
J. Mol. Cell. Cardiol. 39:133-147(2005)

Cross-references
Encyclopedic resources Wikidata; Q54607915
Entry history
Entry creation22-Sep-2015
Last entry update14-Aug-2025
Version number7