Cellosaurus cell line HMC-1 5C6 (CVCL

Cellosaurus HMC-1 5C6 (CVCL_4T80)

Cross-references
Cell line name	HMC-1 5C6
Synonyms	HMC-1(5C6); HMC1-5C6; 5C6
Accession	CVCL_4T80
Resource Identification Initiative	To cite this cell line use: HMC-1 5C6 (RRID:CVCL_4T80)
Comments	Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Mast cell; CL=CL_0000097.
Sequence variations	Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560Gly (c.1679T>G); ClinVar=VCV000375916; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asp816Val (c.2447A>T); ClinVar=VCV000013852; Zygosity=Heterozygous (from parent cell line).
Disease	Mast cell leukemia (NCIt: C3169) Mast cell leukemia (ORDO: Orphanet_98851)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0003 (HMC-1)
Sex of cell	Male
Age at sampling	52Y
Category	Cancer cell line
Publications	PubMed=8950460; DOI=10.1007/BF02505297 Sylvia Weber, Magda Babina, Sabine Kruger-Krasagakes, Andreas Grutzkau, Beate M. Henz; A subclone (5C6) of the human mast cell line HMC-1 represents a more differentiated phenotype than the original cell line. Arch. Dermatol. Res. 288:778-782(1996) PubMed=22363102; DOI=10.1155/2012/274347; PMCID=PMC3272853 Damandeep S. Walia, Mukut Sharma, Vineesh V. Raveendran, Jian-Ping Zhou, Ram Sharma, Daniel J. Stechschulte Jr., Kottarappat N. Dileepan; Human mast cells (HMC-1 5C6) enhance interleukin-6 production by quiescent and lipopolysaccharide-stimulated human coronary artery endothelial cells. Mediators Inflamm. 2012:274347.1-274347.10(2012)
Cell line databases/resources	cancercelllines; CVCL_4T80
Encyclopedic resources	Wikidata; Q54889907
Entry history
Entry creation	22-Sep-2015
Last entry update	19-Dec-2024
Version number	12