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Cellosaurus 48BR (CVCL_4T39)

[Text version]
Cell line name 48BR
Synonyms 48 BRighton
Accession CVCL_4T39
Resource Identification Initiative To cite this cell line use: 48BR (RRID:CVCL_4T39)
Comments Doubling time: 45.5 hours (PubMed=6459055).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WX37 (48BRhTERT)
Sex of cell Female
Age at sampling 48Y
Category Finite cell line
Publications

PubMed=6459055; DOI=10.1111/j.1469-1809.1981.tb00320.x
Joy Dorothy Ann Delhanty, Jennifer M. Parrington, Graham Casey, John Attwood, Lyndsay West, David Kirk, Gerald Corney;
Growth, DNA repair, sister chromatid exchange and chromosome studies in fibroblasts from Huntington's disease patients.
Ann. Hum. Genet. 45:181-198(1981)

DOI=10.1007/978-1-4757-1117-2_12
Colin Francis Arlett, Susan A. Harcourt;
The mutagen sensitivity response of cells from individuals heterozygous for DNA repair deficiency genes.
(In book chapter) The use of human cells for the evaluation of risk from physical and chemical agents; Castellani, Amleto (eds.); pp.155-167; Springer; Boston; USA (1983)

PubMed=6408472; DOI=10.1016/0027-5107(83)90177-X
Ian A. Teo, Colin Francis Arlett, Susan A. Harcourt, Anne Priestley, Bernard C. Broughton;
Multiple hypersensitivity to mutagens in a cell strain (46BR) derived from a patient with immuno-deficiencies.
Mutat. Res. 107:371-386(1983)

PubMed=6600729; DOI=10.1080/09553008314550171
Colin Francis Arlett, Anne Priestley;
Defective recovery from potentially lethal damage in some human fibroblast cell strains.
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 43:157-167(1983)

PubMed=2458832
Alan R. Lehmann, Colin Francis Arlett, Bernard C. Broughton, Susan A. Harcourt, Herdis Steingrimsdottir, Miria Stefanini, Alexander Malcolm R. Taylor, Adayapalam Thyagarajan Natarajan, Stuart Green, Mary D. King, Rona McLeod MacKie ...Show all 13 authors... , John Burdett Primmer Stephenson, John Lorimer Tolmie; Show fewer authors
Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.
Cancer Res. 48:6090-6096(1988)

PubMed=2903889; DOI=10.1080/09553008814552321
Colin Francis Arlett, Michael H.L. Green, Anne Priestley, Susan A. Harcourt, Lynne V. Mayne;
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=2973075; DOI=10.2307/3577479
Bernard Fertil, Patrick J. Deschavanne, Danielle Debieu, Edmond-Philippe Malaise;
Correlation between PLD repair capacity and the survival curve of human fibroblasts in exponential growth phase: analysis in terms of several parameters.
Radiat. Res. 116:74-88(1988)

PubMed=3347209; DOI=10.1016/0167-8817(88)90048-x
Shoshana Squires, Robert T. Johnson;
Kinetic analysis of UV-induced incision discriminates between fibroblasts from different xeroderma pigmentosum complementation groups, XPA heterozygotes and normal individuals.
Mutat. Res. 193:181-192(1988)

PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029
Enriqueta Riballo, Martin Kuhne, Nicole Rief, Aidan J. Doherty, Graeme C.M. Smith, Maria-Jose Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler, Antony R. Parker ...Show all 15 authors... , Stephen Philip Jackson, Andrew R. Gennery, Penelope Ann Jeggo, Markus Lobrich; Show fewer authors
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Mol. Cell 16:715-724(2004)

PubMed=16874298; DOI=10.1038/sj.emboj.7601255; PMCID=PMC1553186
Aaron A. Goodarzi, Ya-Ping Yu, Enriqueta Riballo, Pauline Douglas, Sarah A. Walker, Rui-Qiong Ye, Christine Harer, Caterina Marchetti, Nick Morrice, Penelope Ann Jeggo, Susan P. Lees-Miller;
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
EMBO J. 25:3880-3889(2006)

PubMed=19179371; DOI=10.1093/nar/gkp023; PMCID=PMC2651789
Siripan Limsirichaikul, Atsuko Niimi, Heather Fawcett, Alan R. Lehmann, Shunichi Yamashita, Tomoo Ogi;
A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of ethynyl deoxyuridine (EdU).
Nucleic Acids Res. 37:e31.1-e31.10(2009)

PubMed=22466610; DOI=10.1038/ng.2229
Yuka Nakazawa, Kensaku Sasaki, Norisato Mitsutake, Michiko Matsuse, Mayuko Shimada, Tiziana Nardo, Yoshito Takahashi, Kaname Ohyama, Kosei Ito, Hiroyuki Mishima, Masayo Nomura ...Show all 24 authors... , Akira Kinoshita, Shinji Ono, Katsuya Takenaka, Ritsuko Masuyama, Takashi Kudo, Hanoch Slor, Atsushi Utani, Satoshi Tateishi, Shunichi Yamashita, Miria Stefanini, Alan R. Lehmann, Koh-ichiro Yoshiura, Tomoo Ogi; Show fewer authors
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.
Nat. Genet. 44:586-592(2012)

Cross-references
Encyclopedic resources Wikidata; Q54603308
Experimental variables resources EFO; EFO_0022569
Entry history
Entry creation22-Sep-2015
Last entry update10-Sep-2024
Version number11