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Cellosaurus MM66 (CVCL_4D17)

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Cell line name MM66
Accession CVCL_4D17
Resource Identification Initiative To cite this cell line use: MM66 (RRID:CVCL_4D17)
Comments Characteristics: Established from a patient-derived xenograft (PubMed=24994677).
Doubling time: 80 hours (PubMed=24994677).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=24994677

Markers:
AmelogeninX
CSF1PO12
D5S81812,13
D7S82010
D13S31712,14
D16S53911,13
D21S1128,31
TH016,7
TPOX8,11
vWA14,18

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Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, Andre Nicolas, Amaury Dumont, Guillaume Carita, Jacques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani ...Show all 14 authors... , Xavier Sastre-Garau, Didier Decaudin, Sergio Roman-Roman; Show fewer authors
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4D17
Encyclopedic resources Wikidata; Q54906192
Proteomic databases PRIDE; PXD051055
Entry history
Entry creation22-Sep-2015
Last entry update14-Aug-2025
Version number13