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Cellosaurus MP46 (CVCL_4D13)

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Cell line name MP46
Accession CVCL_4D13
Resource Identification Initiative To cite this cell line use: MP46 (RRID:CVCL_4D13)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Established from a patient-derived xenograft (PubMed=24994677).
Doubling time: 110 hours (PubMed=24994677).
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3298; DepMap=ACH-002011; PubMed=24994677

Markers:
AmelogeninX
CSF1PO11
D3S135818
D5S81812
D7S82011
D8S117911,12,15
D13S31710,12
D16S53912
D18S5113
D21S1130,31
FGA22,22.2,24
Penta D9,12
Penta E12
TH019
TPOX11
vWA16,17

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Publications

PubMed=24994677; DOI=10.1016/j.molonc.2014.06.004; PMCID=PMC5528590
Nabil Amirouchene-Angelozzi, Fariba Nemati, David Gentien, Andre Nicolas, Amaury Dumont, Guillaume Carita, Jacques Camonis, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani ...Show all 14 authors... , Xavier Sastre-Garau, Didier Decaudin, Sergio Roman-Roman; Show fewer authors
Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.
Mol. Oncol. 8:1508-1520(2014)

PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024)

Cross-references
Cell line collections (Providers) ATCC; CRL-3298
Cell line databases/resources cancercelllines; CVCL_4D13
Cell_Model_Passport; SIDM01789
DepMap; ACH-002011
Encyclopedic resources Wikidata; Q54906430
Proteomic databases PRIDE; PXD051055
Entry history
Entry creation22-Sep-2015
Last entry update14-Aug-2025
Version number14