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Cellosaurus KOPT-K1 (CVCL_4965)

[Text version]
Cell line name KOPT-K1
Synonyms KOPT-KI; KOPTK-1; KOPTK1; KopTK1; Koptk1
Accession CVCL_4965
Resource Identification Initiative To cite this cell line use: KOPT-K1 (RRID:CVCL_4965)
Comments Population: Japanese.
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Transcriptomics; RNAseq.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (PubMed=15472075).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
Web pages Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/kopt-k1/
Publications

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=7475267
Wei-Fan Dong, Yi Xu, Qing-Long Hu, David Munroe, Jun Minowada, David E. Housman, Mark David Minden;
Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1.
Leukemia 9:1812-1817(1995)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x; PMCID=PMC5920998
Nobuhiro Kawasaki, Yoshinobu Matsuo, Tadashi Yoshino, Hiroyuki Yanai, Takashi Oka, Norihiro Teramoto, Cao Liu, Eisaku Kondo, Jun Minowada, Tadaatsu Akagi;
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Machiko Kawamura, Hiroaki Ohnishi, Shu-Xia Guo, Xiao-Ming Sheng, Masayoshi Minegishi, Ryoji Hanada, Keizo Horibe, Teruaki Hongo, Yasuhiko Kaneko, Fumio Bessho, Masayoshi Yanagisawa ...Show all 13 authors... , Takao Sekiya, Yasuhide Hayashi; Show fewer authors
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10360377; DOI=10.1038/sj.leu.2401437
Makoto Nakamura, Kanji Sugita, Takeshi Inukai, Kumiko Goi, Kumiko Iijima, Toshiki Tezuka, Satoru Kojika, Kenji Shiraishi, Nariaki Miyamoto, Naoko Karakida, Keiko Kagami ...Show all 14 authors... , Toshiko Koyama-Okazaki, T. Mori, Shinpei Nakazawa; Show fewer authors
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.
Leukemia 13:884-890(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=10995006; DOI=10.1038/sj.leu.2401893
Kumiko Iijima, K. Sugita, T. Inukai, Kumiko Goi, Toshiki Tezuka, K. Uno, H. Sato, Keiko Kagami, Shinpei Nakazawa;
Expression of thrombopoietin receptor and its functional role in human B-precursor leukemia cells with 11q23 translocation or Philadelphia chromosome.
Leukemia 14:1598-1605(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=15472075; DOI=10.1126/science.1102160
Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris 4th, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen Charles Blacklow, Alfred Thomas Look, Jon Christopher Aster;
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Kinuko Hirose, Takeshi Inukai, Jiro Kikuchi, Yusuke Furukawa, Tomokatsu Ikawa, Hiroshi Kawamoto, S. Helen Oram, Berthold Gottgens, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Hajime Okita ...Show all 22 authors... , Koshi Akahane, Xiao-Chun Zhang, Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Hidemitsu Kurosawa, Alfred Thomas Look, Hirotaka Matsui, Toshiya Inaba, Kanji Sugita; Show fewer authors
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=28569787; DOI=10.1038/cddis.2017.249; PMCID=PMC5520907
Shin Kasai, Yoshiyuki Furuichi, Norie Ando, Keiko Kagami, Masako Abe, Takaya Nakane, Kumiko Goi, Takeshi Inukai, Sei Saitoh, Shinichi Ohno, Shogo Okazaki ...Show all 14 authors... , Osamu Nagano, Hideyuki Saya, Kanji Sugita; Show fewer authors
Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.
Cell Death Dis. 8:e2857.1-e2857.11(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4965
Anatomy/cell type resources BTO; BTO_0004964
Biological sample resources ENCODE; ENCBS345YKN
ENCODE; ENCBS869LIS
Chemistry resources ChEMBL-Cells; CHEMBL4483146
ChEMBL-Targets; CHEMBL4483252
PubChem_Cell_line; CVCL_4965
Encyclopedic resources Wikidata; Q54900335
Experimental variables resources EFO; EFO_0006283
Gene expression databases GEO; GSM3145584
GEO; GSM3145713
Polymorphism and mutation databases Cosmic; 721714
Cosmic; 913407
Cosmic; 944545
Cosmic; 998730
Cosmic; 1037683
Cosmic; 1115584
Cosmic; 1151783
Cosmic; 1224374
Cosmic; 1524801
Cosmic; 1641389
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number22