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Cellosaurus XG-3 (CVCL_4799)

[Text version]
Cell line name XG-3
Synonyms XG3; XG 3; XG-3P; XG3P
Accession CVCL_4799
Resource Identification Initiative To cite this cell line use: XG-3 (RRID:CVCL_4799)
Comments Characteristics: Produces Ig lambda.
Characteristics: IL6 dependent.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Unspecified (PubMed=21173094).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=21173094).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*02,32
HLA-BB*35,44
HLA-CC*04,05
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_HX21 ! XG-3E
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

PubMed=1753108; DOI=10.4049/jimmunol.147.12.4402
Jourdan M., Zhang X.-G., Portier M., Boiron J.-M., Bataille R., Klein B.
IFN-alpha induces autocrine production of IL-6 in myeloma cell lines.
J. Immunol. 147:4402-4407(1991)

PubMed=1373872
Mazars G.-R., Portier M., Zhang X.-G., Jourdan M., Bataille R., Theillet C., Klein B.
Mutations of the p53 gene in human myeloma cell lines.
Oncogene 7:1015-1018(1992)

PubMed=8204890; DOI=10.1182/blood.V83.12.3654.3654
Zhang X.-G., Gaillard J.-P., Robillard N., Lu Z.-Y., Gu Z.-J., Jourdan M., Boiron J.-M., Bataille R., Klein B.
Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma.
Blood 83:3654-3663(1994)

DOI=10.1007/0-306-46877-8_4
Jernberg-Wiklund H., Nilsson K.
Multiple myeloma cell lines.
(In) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=21173094; DOI=10.3324/haematol.2010.033456
Moreaux J., Klein B., Bataille R., Descamps G., Maiga S., Hose D., Goldschmidt H., Jauch A., Reme T., Jourdan M., Amiot M., Pellat-Deceunynck C.
A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines.
Haematologica 96:574-582(2011)

PubMed=30545397; DOI=10.1186/s13045-018-0679-0
Tessoulin B., Moreau-Aubry A., Descamps G., Gomez-Bougie P., Maiga S., Gaignard A., Chiron D., Menoret E., Le Gouill S., Moreau P., Amiot M., Pellat-Deceunynck C.
Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
J. Hematol. Oncol. 11:137.1-137.13(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4799
Encyclopedic resources Wikidata; Q54994710
Gene expression databases ArrayExpress; E-TABM-937
Polymorphism and mutation databases Cosmic; 742960
Cosmic; 2809770
IARC_TP53; 28498
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21