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Cellosaurus LNCaP-abl (CVCL_4793)

[Text version]
Cell line name LNCaP-abl
Synonyms LNCaP-androgen ablation
Accession CVCL_4793
Resource Identification Initiative To cite this cell line use: LNCaP-abl (RRID:CVCL_4793)
Comments Population: Caucasian.
Characteristics: Established after 10 months of propagation of LNCaP in steroid-depleted medium.
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptome analysis by RNAseq.
Misspelling: LNCaP-abI; BTO=BTO:0006467.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=10496349; DOI=10.1038/sj.bjc.6690684
Culig Z., Hoffmann J., Erdel M., Eder I.E., Hobisch A., Hittmair A., Bartsch G., Utermann G., Schneider M.R., Parczyk K., Klocker H.
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system.
Br. J. Cancer 81:242-251(1999)

PubMed=34402095; DOI=10.1002/pros.24210
Haffner M.C., Bhamidipati A., Tsai H.K., Esopi D.M., Vaghasia A.M., Low J.-Y., Patel R.A., Guner G., Pham M.-T., Castagna N., Hicks J.L., Wyhs N., Aebersold R., De Marzo A.M., Nelson W.G., Guo T.-N., Yegnasubramanian S.
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4793
Anatomy/cell type resources BTO; BTO:0006467
Encyclopedic resources Wikidata; Q54902830
Gene expression databases GEO; GSM3145719
GEO; GSM5402195
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23