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Cellosaurus LNCaP-abl (CVCL_4793)

[Text version]
Cell line name LNCaP-abl
Synonyms LNCaP-ABL; LNCaP-androgen ablation
Accession CVCL_4793
Resource Identification Initiative To cite this cell line use: LNCaP-abl (RRID:CVCL_4793)
Comments Population: Caucasian.
Characteristics: Established after 10 months of propagation of LNCaP in steroid-depleted medium.
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptomics; RNAseq.
Misspelling: LNCaP-abI; BTO=BTO_0006467.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=10496349; DOI=10.1038/sj.bjc.6690684; PMCID=PMC2362859
Zoran Culig, Jens Hoffmann, Martin Erdel, Iris Elisabeth Eder, Alfred Hobisch, Anton Hittmair, Georg Bartsch, Gerd W. Utermann, Martin R. Schneider, Karsten Parczyk, Helmut Klocker;
Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system.
Br. J. Cancer 81:242-251(1999)

PubMed=34402095; DOI=10.1002/pros.24210; PMCID=PMC8460612
Michael C. Haffner, Akshay Bhamidipati, Harrison K. Tsai, David M. Esopi, Ajay M. Vaghasia, Jin-Yih Low, Radhika A. Patel, Gunes Guner, Minh-Tam Pham, Nicole Castagna, Jessica L. Hicks ...Show all 17 authors... , Nicolas Wyhs, Rudolf Aebersold, Angelo M. De Marzo, William George Nelson, Tian-Nan Guo, Srinivasan Yegnasubramanian; Show fewer authors
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Prostate 81:1159-1171(2021)

PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770
Erica L. Beatson, Emily N. Risdon, Giulia C. Napoli, Douglas K. Price, Cindy H. Chau, William Douglas Figg Sr.;
Genomic characterization of preclinical prostate cancer cell line models.
Int. J. Mol. Sci. 25:6111.1-6111.19(2024)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4793
Anatomy/cell type resources BTO; BTO_0006467
Encyclopedic resources Wikidata; Q54902830
Gene expression databases GEO; GSM3145603
GEO; GSM3145719
GEO; GSM5402195
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number26