Cellosaurus logo
expasy logo

Cellosaurus LNCaP C4 (CVCL_4783)

[Text][XML][JSON]
Cell line name LNCaP C4
Synonyms LNCaP-C4; LNCaPC4; LNCaP subline C4; C4
Accession CVCL_4783
Resource Identification Initiative To cite this cell line use: LNCaP C4 (RRID:CVCL_4783)
Comments Population: Caucasian.
Characteristics: Derived from a tumor that developed in castrated nude mice injected with LNCaP cells.
Doubling time: ~24-36 hours (ATCC=CRL-3313); 26.30 hours (JWGray panel).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Children:
CVCL_4782 (LNCaP C4-2)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3313

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811,12
D7S8209,9.1,10.3
D13S31710,11
D16S53911
TH019
TPOX8,9
vWA16,18,19

Run an STR similarity search on this cell line
Web pages Info; Wikipedia; -; https://en.wikipedia.org/wiki/LNCaP
Publications

PubMed=8169003; DOI=10.1002/ijc.2910570319
Hsi-Chin Wu, Jer-Tsong Hsieh, Martin E. Gleave, Nicholas M. Brown, Sen Pathak, Leland W.K. Chung;
Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells.
Int. J. Cancer 57:406-412(1994)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065; PMCID=PMC9153264
Cory Abate-Shen, Francisca Nunes de Almeida;
Establishment of the LNCaP cell line -- the dawn of an era for prostate cancer research.
Cancer Res. 82:1689-1691(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-3313
Cell line databases/resources cancercelllines; CVCL_4783
Anatomy/cell type resources BTO; BTO_0005868
Encyclopedic resources Wikidata; Q54902813
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26