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Cellosaurus PPC-1 (CVCL_4778)

[Text version]
Cell line name PPC-1
Synonyms Primary Prostate Carcinoma-1; Specimen P-3
Accession CVCL_4778
Resource Identification Initiative To cite this cell line use: PPC-1 (RRID:CVCL_4778)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=11304728; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from a 67 year old male patient with prostate carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00153.
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-190; PubMed=11304728

Markers:
AmelogeninX
CSF1PO11
D3S135816
D5S81813
D7S8208,11
D8S117913
D13S31711
D16S53911
D18S5114,15
D21S1129,31.2
FGA24
TH016,7
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages Info; CaP CLDb; -; https://web.archive.org/web/20160321231613/http://capcelllines.ca/details.asp?id=171
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=2583869; DOI=10.1002/ijc.2910440525
Arthur R. Brothman, Lori Jean Lesho, Kenneth D. Somers, George L. Wright Jr., Donald J. Merchant;
Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma.
Int. J. Cancer 44:898-903(1989)

PubMed=2016798; DOI=10.1016/S0022-5347(17)38540-3
Arthur R. Brothman, Perry C. Wilkins, Elizabeth W. Sales, Kenneth D. Somers;
Metastatic properties of the human prostatic cell line, PPC-1, in athymic nude mice.
J. Urol. 145:1088-1091(1991)

PubMed=8616865
Yoshinori S. Murakami, Hans Albertsen, Arthur R. Brothman, Robin Jean Leach, Raymond Leslie White;
Suppression of the malignant phenotype of human prostate cancer cell line PPC-1 by introduction of normal fragments of human chromosome 10.
Cancer Res. 56:2157-2160(1996)

PubMed=11304728; DOI=10.1002/pros.1045
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller;
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=15486987; DOI=10.1002/pros.20158
Hong-Juan Zhao, Young Kim, Pei Wang, Jacques Lapointe, Robert Tibshirani, Jonathan R. Pollack, James D. Brooks;
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) ATCC; HTB-190 - Discontinued
Cell line databases/resources cancercelllines; CVCL_4778
Anatomy/cell type resources BTO; BTO_0001062
Biological sample resources BioSample; SAMN03151895
Chemistry resources ChEMBL-Cells; CHEMBL3307780
ChEMBL-Targets; CHEMBL1626502
PubChem_Cell_line; CVCL_4778
Encyclopedic resources Wikidata; Q54947777
Gene expression databases GEO; GSM91929
Polymorphism and mutation databases Cosmic; 948074
Progenetix; CVCL_4778
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31