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Cellosaurus ALVA-31 (CVCL_4737)

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Cell line name ALVA-31
Synonyms ALVA 31; ALVA31; American Lake VA-31
Accession CVCL_4737
Resource Identification Initiative To cite this cell line use: ALVA-31 (RRID:CVCL_4737)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=11304728; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from the tumor mass removed during a radical prostatectomy in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00173.
Population: Caucasian.
Doubling time: ~26 hours (PubMed=7681207); 23 hours (PubMed=8561862).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): PubMed=11304728

Markers:
AmelogeninX
D3S135816
D5S81813,14
D7S8208,11,12
D8S117913
D13S31711
D18S5115
D21S1129,31.2
FGA24
vWA17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=7681207; DOI=10.1002/pros.2990220202
Steven M. Loop, Thomas A. Rozanski, Richard C. Ostenson;
Human primary prostate tumor cell line, ALVA-31: a new model for studying the hormonal regulation of prostate tumor cell growth.
Prostate 22:93-108(1993)

PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O
Parmender P. Mehta, Balakrishna L. Lokeshwar, Paul C. Schiller, Marcelo V. Bendix, Richard C. Ostenson, Guy A. Howard, Bernard A. Roos;
Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP.
Mol. Carcinog. 15:18-32(1996)

PubMed=11304728; DOI=10.1002/pros.1045
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller;
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4737
Anatomy/cell type resources BTO; BTO_0003850
Biological sample resources BioSample; SAMN03151889
Encyclopedic resources Wikidata; Q54749373
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28