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Cellosaurus ALVA-31 (CVCL_4737)

[Text version]
Cell line name ALVA-31
Synonyms ALVA 31; ALVA31; American Lake VA-31
Accession CVCL_4737
Resource Identification Initiative To cite this cell line use: ALVA-31 (RRID:CVCL_4737)
Comments Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=11304728; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from the tumor mass removed during a radical prostatectomy in a patient with well differentiated, stage B2, adenocarcinoma of the prostate.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00173.
Population: Caucasian.
Doubling time: ~26 hours (PubMed=7681207); 23 hours (PubMed=8561862).
Derived from site: Metastatic; Bone; UBERON=UBERON_0002481.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (PubMed=11304728).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0035 (PC-3)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): PubMed=11304728


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=7681207; DOI=10.1002/pros.2990220202
Loop S.M., Rozanski T.A., Ostenson R.C.
Human primary prostate tumor cell line, ALVA-31: a new model for studying the hormonal regulation of prostate tumor cell growth.
Prostate 22:93-108(1993)

PubMed=8561862; DOI=10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O
Mehta P.P., Lokeshwar B.L., Schiller P.C., Bendix M.V., Ostenson R.C., Howard G.A., Roos B.A.
Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP.
Mol. Carcinog. 15:18-32(1996)

PubMed=11304728; DOI=10.1002/pros.1045
van Bokhoven A., Varella-Garcia M., Korch C.T., Hessels D., Miller G.J.
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Russell P.J., Kingsley E.A.
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

van Bokhoven A.
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004), Katholieke Universiteit Nijmegen, Netherlands

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line databases/resources cancercelllines; CVCL_4737
Anatomy/cell type resources BTO; BTO:0003850
Biological sample resources BioSample; SAMN03151889
Encyclopedic resources Wikidata; Q54749373
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number26