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Cellosaurus PK-8 (CVCL_4718)

[Text version]

Cell line name PK-8
Synonyms PK8
Accession CVCL_4718
Resource Identification Initiative To cite this cell line use: PK-8 (RRID:CVCL_4718)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Characteristics: Established from a xenograft.
Doubling time: 56 hours (PubMed=3547771).
Omics: Deep RNAseq analysis.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Sequence variations
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Liver.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO10,12
D3S135816
D5S81813
D7S8209,12
D8S117913,15
D13S31711
D16S5399,10
D18S5113
D21S1131
FGA23 (PubMed=25877200)
23,26 (DepMap)
Penta D9
Penta E13,15
TH017
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=3547771; DOI=10.1620/tjem.150.231
Kobari M., Hisano H., Matsuno S., Sato T., Kan M., Tachibana T.
Establishment of six human pancreatic cancer cell lines and their sensitivities to anti-tumor drugs.
Tohoku J. Exp. Med. 150:231-248(1986)

PubMed=11115575; DOI=10.3892/or.8.1.89
Sun C., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721
Calhoun E.S., Hucl T., Gallmeier E., West K.M., Arking D.E., Maitra A., Iacobuzio-Donahue C.A., Chakravarti A., Hruban R.H., Kern S.E.
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer Res. 66:7920-7928(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112
Daemen A., Peterson D., Sahu N., McCord R., Du X.-N., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R.L., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

Cross-references
Cell line collections RCB; RCB2096 - Discontinued
RCB; RCB2700
TKG; TKG 0383
Cell line databases/resources CLO; CLO_0050112
DepMap; ACH-002039
Anatomy/cell type resources BTO; BTO:0004855
Biological sample resources BioSample; SAMN03472951
Chemistry resources PharmacoDB; PK8_1269_2019
Encyclopedic resources Wikidata; Q54947454
Experimental variables resources EFO; EFO_0006737
Gene expression databases ArrayExpress; E-MTAB-2706
Polymorphism and mutation databases Cosmic; 707254
Cosmic; 1066177
Cosmic; 1644298
IARC_TP53; 14302
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number20