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Cellosaurus NMS-2 (CVCL_4662)

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Cell line name NMS-2
Accession CVCL_4662
Resource Identification Initiative To cite this cell line use: NMS-2 (RRID:CVCL_4662)
Comments Population: Japanese.
Doubling time: 50.2 hours (PubMed=9849858).
Karyotypic information: Average ploidy of 4.56 (PubMed=36818284).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Thigh; UBERON=UBERON_0000376.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous; Note=By translocation (PubMed=34059954).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=34059954).
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=36818284).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; c.7062+1G>T (c.6999+1G>T); ClinVar=VCV000803375; Zygosity=Heterozygous; Note=Splice donor mutation. Somatic (PubMed=36818284).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L810 ! NMS-2PC
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2347; PubMed=36818284

Markers:
AmelogeninX,Y
CSF1PO12
D2S133818,19
D3S135815,16
D5S81812,13
D7S8209,12
D8S117912,13
D13S31712
D16S5399
D18S5117
D19S43313.2,14.2
D21S1130
FGA21,22
TH016
TPOX8,9
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=9849858; DOI=10.1007/s004280050271
Satoshi Imaizumi, Teiichi Motoyama, Akira Ogose, Tetsuo Hotta, Hideaki E. Takahashi;
Characterization and chemosensitivity of two human malignant peripheral nerve sheath tumour cell lines derived from a patient with neurofibromatosis type 1.
Virchows Arch. 433:435-441(1998)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Alexander Pemov, Hua Li, William Presley, Margaret R. Wallace, David T. Miller;
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=34059954; DOI=10.1007/s00439-021-02296-x
Miriam Magallon-Lorenz, Juana Fernandez-Rodriguez, Ernest Terribas, Edgar Creus-Bachiller, Cleofe Romagosa, Anna Estival, Diana Perez Sidelnikova, Hector Salvador, Alberto Villanueva, Ignacio Blanco, Meritxell Carrio ...Show all 14 authors... , Conxi Lazaro, Eduard Serra, Bernat Gel; Show fewer authors
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Hum. Genet. 140:1241-1252(2021)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Miriam Magallon-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernandez, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausova ...Show all 28 authors... , Elisabeth Castellanos, Ignacio Blanco, George Henry DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Victor-Felix Mautner, Lan Kluwe, Nancy Ratner, Margaret R. Wallace, Juana Fernandez-Rodriguez, Conxi Lazaro, Jonathan A. Fletcher, David E. Reuss, Meritxell Carrio, Bernat Gel, Eduard Serra; Show fewer authors
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

Cross-references
Cell line collections (Providers) RCB; RCB2347
Cell line databases/resources CLO; CLO_0050138
Biological sample resources BioSample; SAMN03471965
Encyclopedic resources Wikidata; Q54930841
Polymorphism and mutation databases Cosmic; 1319814
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number15