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Cellosaurus NMS-2 (CVCL_4662)

[Text version]
Cell line name NMS-2
Accession CVCL_4662
Resource Identification Initiative To cite this cell line use: NMS-2 (RRID:CVCL_4662)
Comments Population: Japanese.
Doubling time: 50.2 hours (PubMed=9849858).
Karyotypic information: Average ploidy of 4.56 (PubMed=36818284).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Thigh; UBERON=UBERON_0000376.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous; Note=By translocation (PubMed=34059954).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=34059954).
  • Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=36818284).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; c.7062+1G>T (c.6999+1G>T); ClinVar=VCV000803375; Zygosity=Heterozygous; Note=Splice donor mutation. Somatic (PubMed=36818284).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L810 ! NMS-2PC
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2347; PubMed=36818284

Markers:
AmelogeninX,Y
CSF1PO12
D2S133818,19
D3S135815,16
D5S81812,13
D7S8209,12
D8S117912,13
D13S31712
D16S5399
D18S5117
D19S43313.2,14.2
D21S1130
FGA21,22
TH016
TPOX8,9
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=9849858; DOI=10.1007/s004280050271
Imaizumi S., Motoyama T., Ogose A., Hotta T., Takahashi H.E.
Characterization and chemosensitivity of two human malignant peripheral nerve sheath tumour cell lines derived from a patient with neurofibromatosis type 1.
Virchows Arch. 433:435-441(1998)

PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:i50-i61(2020)

PubMed=34059954; DOI=10.1007/s00439-021-02296-x
Magallon-Lorenz M., Fernandez-Rodriguez J., Terribas E., Creus-Bachiller E., Romagosa C., Estival A., Perez Sidelnikova D., Salvador H., Villanueva A., Blanco I., Carrio M., Lazaro C., Serra E., Gel B.
Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation.
Hum. Genet. 140:1241-1252(2021)

PubMed=36818284; DOI=10.1016/j.isci.2023.106096; PMCID=PMC9929861
Magallon-Lorenz M., Terribas E., Ortega-Bertran S., Creus-Bachiller E., Fernandez M., Requena G., Rosas I., Mazuelas H., Uriarte-Arrazola I., Negro A., Lausova T., Castellanos E., Blanco I., DeVries G.H., Kawashima H., Legius E., Brems H., Mautner V.-F., Kluwe L., Ratner N., Wallace M.R., Fernandez-Rodriguez J., Lazaro C., Fletcher J.A., Reuss D.E., Carrio M., Gel B., Serra E.
Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis.
iScience 26:106096.1-106096.22(2023)

Cross-references
Cell line collections (Providers) RCB; RCB2347
Cell line databases/resources CLO; CLO_0050138
Biological sample resources BioSample; SAMN03471965
Encyclopedic resources Wikidata; Q54930841
Polymorphism and mutation databases Cosmic; 1319814
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number15