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Cellosaurus 888-mel (CVCL_4632)

[Text version]
Cell line name 888-mel
Synonyms 888-MEL; 888 mel; 888mel; 888MEL; 888; Mel888; mel888; MG-888
Accession CVCL_4632
Resource Identification Initiative To cite this cell line use: 888-mel (RRID:CVCL_4632)
Comments From: Rosenberg, Steven A.; Surgery Branch, National Cancer Institute, National Institutes of Health; Bethesda; USA.
Population: Caucasian.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Oral cavity, soft palate, hypodermis; UBERON=UBERON_0001733+UBERON_0002072.
Sequence variations
HLA typing Source: PubMed=9670966
Class I
HLA-AA*01,24
HLA-BB*52,55
HLA-CC*01:02,12:01
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C612 (888A2 mel)
Originate from same individual CVCL_7943 ! 1290-mel
CVCL_DI11 ! 1858-mel a
CVCL_DI12 ! 1858-mel b
CVCL_DI13 ! 1858-mel c
CVCL_DI14 ! 1936-mel
CVCL_DI15 ! 1962-mel
CVCL_A1DN ! 888-EBV
Sex of cell Female
Age at sampling 26Y
Category Cancer cell line
Web pages Provider; NIH OTT; E-070-2010/0-8; https://web.archive.org/web/20150923174650/http://www.ott.nih.gov/erma/metastatic-melanoma-cancer-cell-line-888-mel
Publications

PubMed=8027550; DOI=10.4049/jimmunol.153.3.1225
Francesco M. Marincola, Peter Shamamian, Richard B. Alexander, James R. Gnarra, Regina L. Turetskaya, Sergei Arturovich Nedospasov, Toni B. Simonis, Jeffery Karl Taubenberger, John R. Yannelli, Arnold Mixon, Nicholas P. Restifo ...Show all 13 authors... , Meenhard Herlyn, Steven A. Rosenberg; Show fewer authors
Loss of HLA haplotype and B locus down-regulation in melanoma cell lines.
J. Immunol. 153:1225-1237(1994)

PubMed=8081556; DOI=10.1097/00002371-199407000-00002; PMCID=PMC2561308
Francesco M. Marincola, Peter Shamamian, Toni B. Simonis, Andrea D. Abati, Julia A. Hackett, Teresita O'Dea, Patricia A. Fetsch, John R. Yannelli, Nicholas P. Restifo, James J. Mule, Steven A. Rosenberg;
Locus-specific analysis of human leukocyte antigen class I expression in melanoma cell lines.
J. Immunother. Emphasis Tumor Immunol. 16:13-23(1994)

PubMed=8537970; DOI=10.1093/jnci/88.2.100; PMCID=PMC2248456
Nicholas P. Restifo, Francesco M. Marincola, Yutaka Kawakami, Jeffery Karl Taubenberger, John R. Yannelli, Steven A. Rosenberg;
Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy.
J. Natl. Cancer Inst. 88:100-108(1996)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Graeme J. Walker, Jose F. Flores, J. Michael Glendening, Amy Hsiu-Ti Lin, Isabel D.C. Markl, Jane W. Fountain;
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

PubMed=9670966; DOI=10.4049/jimmunol.161.2.877
Maria P. Bettinotti, Christina J. Kim, Kang-Hun Lee, Matthew Roden, Janice N. Cormier, Monica C. Panelli, Kenneth K. Parker, Francesco M. Marincola;
Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy.
J. Immunol. 161:877-889(1998)

PubMed=10048982; DOI=10.1002/(SICI)1097-0215(19990301)80:5<781::AID-IJC24>3.0.CO;2-A; PMCID=PMC2072935
Janice N. Cormier, Monica C. Panelli, Julia A. Hackett, Maria P. Bettinotti, Arnold Mixon, John R. Wunderlich, Linda L. Parker, Nicholas P. Restifo, Soldano Ferrone, Francesco M. Marincola;
Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model.
Int. J. Cancer 80:781-790(1999)

PubMed=10754339; DOI=10.4049/jimmunol.164.8.4382
Monica C. Panelli, Maria P. Bettinotti, Kate Lally, Galen Anthony Ohnmacht, Yong Li, Paul F. Robbins, Adam Riker, Steven A. Rosenberg, Francesco M. Marincola;
A tumor-infiltrating lymphocyte from a melanoma metastasis with decreased expression of melanoma differentiation antigens recognizes MAGE-12.
J. Immunol. 164:4382-4392(2000)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Hideaki Tanami, Issei Imoto, Akira Hirasawa, Yasuhiro Yuki, Itaru Sonoda, Jun Inoue, Kohichiroh Yasui, Akiko Misawa-Furihata, Yutaka Kawakami, Johji Inazawa;
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=16470173; DOI=10.1038/sj.jid.5700193
Ena Wang, Sonia Voiculescu, Isabelle Caroline Le Poole, Mona El-Gamil, Xin Li, Marianna Sabatino, Paul F. Robbins, Brian J. Nickoloff, Francesco M. Marincola;
Clonal persistence and evolution during a decade of recurrent melanoma.
J. Invest. Dermatol. 126:1372-1377(2006)

PubMed=18172304; DOI=10.1158/0008-5472.CAN-07-1939
Marianna Sabatino, Ying-Dong Zhao, Sonia Voiculescu, Alessandro Monaco, Paul F. Robbins, Laszlo Karai, Brian J. Nickoloff, Michele Maio, Silvia Selleri, Francesco M. Marincola, Ena Wang;
Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis.
Cancer Res. 68:122-131(2008)

PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333
Judith Muller, Oscar Krijgsman, Jennifer Tsoi, Lidia Robert, Willy Hugo, Chunying Song, Xiang-Ju Kong, Patricia Abrao Possik, Paulien D.M. Cornelissen-Steijger, Marnix H. Geukes Foppen, Kristel Kemper ...Show all 19 authors... , Colin Ronald Goding, Ultan McDermott, Christian Blank, John B.A.G. Haanen, Thomas G. Graeber, Antoni Ribas, Roger S. Lo, Daniel S. Peeper; Show fewer authors
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5:5712.1-5712.15(2014)

PubMed=25538140; DOI=10.15252/msb.20145450; PMCID=PMC4300494
Marjon A. Smit, Gianluca Maddalo, Kylie Greig, Linsey M. Raaijmakers, Patricia Abrao Possik, Bas van Breukelen, Salvatore Cappadona, Albert J.R. Heck, A.F. Maarten Altelaar, Daniel S. Peeper;
ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma.
Mol. Syst. Biol. 10:772-772(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4632
CGH-DB; 9308-4
Anatomy/cell type resources BTO; BTO_0002950
Chemistry resources PharmacoDB; 888mel_32_2019
Encyclopedic resources Wikidata; Q54605471
Experimental variables resources EFO; EFO_0006531
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206439
GEO; GSM218046
GEO; GSM274691
GEO; GSM1092556
GEO; GSM1507930
Polymorphism and mutation databases Cosmic; 876679
Cosmic; 877281
Cosmic; 905221
Cosmic; 1042621
Cosmic; 1238108
Cosmic; 1303045
Progenetix; CVCL_4632
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31