| Cell line name |
OE50 |
|---|
| Synonyms |
OE-50; JROECL 50; JROECL50 |
|---|
| Accession |
CVCL_4628 |
|---|
| Resource Identification Initiative |
To cite this cell line use: OE50 (RRID:CVCL_4628) |
|---|
| Comments |
Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (PubMed=10789716). Originally thought to originate from a 71 year old female patient with an esophageal squamous cell carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00547.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Colon carcinoma (NCIt: C4910) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
48Y |
|---|
| Category |
Cancer cell line |
|---|
| Web pages |
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
|---|
| Publications | PubMed=9010035; DOI=10.1038/bjc.1997.42; PMCID=PMC2063267
John C. Rockett, K. Larkin, S. Jane Darnton, Alan G. Morris, Hugoe R. Matthews;
Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization.
Br. J. Cancer 75:258-263(1997) PubMed=10789716; DOI=10.1054/bjoc.1999.1170; PMCID=PMC2363398
Bas P.L. Wijnhoven, Marcel G.J. Tilanus, Alan G. Morris, S. Jane Darnton, Hugo W. Tilanus, Winand N.M. Dinjens;
Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50 are admixtures of the human colon carcinoma cell line HCT 116.
Br. J. Cancer 82:1510-1512(2000) PubMed=23795680; DOI=10.1111/dote.12095
Jurjen J. Boonstra, Hugo W. Tilanus, Winand N.M. Dinjens;
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
ECACC; 96061337 - Discontinued
|
|---|
| Cell line databases/resources |
CLO; CLO_0008242
CLDB; cl3764
cancercelllines; CVCL_4628
|
|---|
| Encyclopedic resources |
Wikidata; Q54931867
|
|---|
| Polymorphism and mutation databases |
Cosmic; 997863
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 25 |
|---|
