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Cellosaurus CHO-xrs-5 (CVCL_4601)

[Text version]
Cell line name CHO-xrs-5
Synonyms CHO-XRS5; CHO-xrs5; CHO Xrs5; XRS-5; Xrs-5; xrs-5; xrs 5; XrS5; xrs5
Accession CVCL_4601
Resource Identification Initiative To cite this cell line use: CHO-xrs-5 (RRID:CVCL_4601)
Comments Characteristics: Sensitive to X-ray. Has a defect in double-strand break rejoining (PubMed=6513971).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6197643; DOI=10.1016/0167-8817(83)90026-3
Penelope Ann Jeggo, Lynn M. Kemp;
X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents.
Mutat. Res. 112:313-327(1983)

PubMed=6513971; DOI=10.1016/0167-8817(84)90037-3
Lynn M. Kemp, Steven G. Sedgwick, Penelope Ann Jeggo;
X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining.
Mutat. Res. 132:189-196(1984)

PubMed=2564870; DOI=10.1080/09553008914550651
Julie Denekamp, Gordon Francis Whitmore, Penelope Ann Jeggo;
Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence?
Int. J. Radiat. Biol. 55:605-617(1989)

PubMed=2218721; DOI=10.1007/BF01232460
Wayne P. Wahls, Peter D. Moore;
Relative frequencies of homologous recombination between plasmids introduced into DNA repair-deficient and other mammalian somatic cell lines.
Somat. Cell Mol. Genet. 16:321-329(1990)

PubMed=7603335; DOI=10.1093/mutage/10.2.91
Guo-Jian Liu, Shirley Lehnert, Terry Y.-K. Chow;
Mammalian endo-exonuclease activity and its level in various radiation sensitive cell lines.
Mutagenesis 10:91-94(1995)

PubMed=9032253; DOI=10.1128/mcb.17.3.1264; PMCID=PMC231851
Belinda K. Singleton, Anne Priestley, Herdis Steingrimsdottir, David Gell, Tracy Blunt, Stephen Philip Jackson, Alan R. Lehmann, Penelope Ann Jeggo;
Molecular and biochemical characterization of xrs mutants defective in Ku80.
Mol. Cell. Biol. 17:1264-1273(1997)

PubMed=22923057; DOI=10.3892/or.2012.1982
Stefan C. Genet, Junko Maeda, Hiroshi Fujisawa, Charles R. Yurkon, Yoshihiro Fujii, Ashley M. Romero, Paula C. Genik, Akira Fujimori, Hisashi Kitamura, Takamitsu A. Kato;
Comparison of cellular lethality in DNA repair-proficient or -deficient cell lines resulting from exposure to 70 MeV/n protons or 290 MeV/n carbon ions.
Oncol. Rep. 28:1591-1596(2012)

Cross-references
Cell line collections (Providers) ATCC; CRL-2348
Cell line databases/resources CLO; CLO_0009691
Encyclopedic resources Wikidata; Q54813131
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number11