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Cellosaurus LIM2550 (CVCL_4442)

[Text version]
Cell line name LIM2550
Synonyms LIM 2550; LIM-2550
Accession CVCL_4442
Resource Identification Initiative To cite this cell line use: LIM2550 (RRID:CVCL_4442)
Comments From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
Microsatellite instability: Instable (MSI) (PubMed=19378335; PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Heterozygous (PubMed=19378335).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=19378335).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly245Asp (c.734G>A); ClinVar=VCV000012355; Zygosity=Unspecified (PubMed=19378335).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): CBA; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,23
D3S135815,18
D5S81812,13
D7S8209,10
D8S117914,15
D13S31712,15
D16S5399,14
D18S5113,14
D19S43311,14
D21S1129,31.2
FGA21,22
TH018,9
TPOX8
vWA14,19

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Publications

PubMed=19378335; DOI=10.1002/ijc.24289
Zhang H.-H., Walker F., Kiflemariam S., Whitehead R.H., Williams D., Phillips W.A., Mikeska T., Dobrovic A., Burgess A.W.
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line collections (Providers) CBA; CBA-0169
ECACC; 12070504
Cell line databases/resources cancercelllines; CVCL_4442
ColonAtlas; LIM2550
Biological sample resources BioSample; SAMN07624417
Encyclopedic resources Wikidata; Q54902540
Gene expression databases GEO; GSM1448168
Polymorphism and mutation databases Cosmic; 1238058
Cosmic; 1486140
Cosmic; 1805262
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25