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Cellosaurus LIM1899 (CVCL_4435)

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Cell line name LIM1899
Synonyms Lim1899; LIM 1899; LIM-1899
Accession CVCL_4435
Resource Identification Initiative To cite this cell line use: LIM1899 (RRID:CVCL_4435)
Comments From: Ludwig Institute for Cancer Research, Melbourne Branch; Melbourne; Australia.
Doubling time: 48 hours (PubMed=1427983).
Microsatellite instability: Stable (MSS) (PubMed=19378335).
Microsatellite instability: Instable (MSI) (PubMed=24755471; PubMed=25926053).
Omics: Glycomics; N-glycan profiling.
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CBA=CBA-0163; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO10 (PubMed=25926053)
10,11 (CBA=CBA-0163)
D2S133820,24
D3S135813,15,16
D5S81811,12,14 (CBA=CBA-0163)
11,14 (PubMed=25926053)
D7S8208,9
D8S117910,11
D13S3179,12
D16S53911 (PubMed=25926053)
11,12 (CBA=CBA-0163)
D18S5112
D19S43313,14
D21S1129 (PubMed=25926053)
29,30 (CBA=CBA-0163)
FGA19,20,22
TH016,9.3
TPOX9,11
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=2386931
Sarah M. Andrew, Jin Ghee Teh, Ricky W. Johnstone, Sarah May Russell, Robert H. Whitehead, Ian F.C. McKenzie, Geoffrey A. Pietersz;
Tumor localization by combinations of monoclonal antibodies in a new human colon carcinoma cell line (LIM1899).
Cancer Res. 50:5225-5230(1990)

PubMed=1427983; DOI=10.1038/icb.1992.30
Robert H. Whitehead, Hui-Hua Zhang, Ian P. Hayward;
Retention of tissue-specific phenotype in a panel of colon carcinoma cell lines: relationship to clinical correlates.
Immunol. Cell Biol. 70:227-236(1992)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=19378335; DOI=10.1002/ijc.24289
Hui-Hua Zhang, Francesca E. Walker, Sara Kiflemariam, Robert H. Whitehead, David Williams, Wayne A. Phillips, Thomas Mikeska, Alexander Dobrovic, Antony Wilks Burgess;
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
Int. J. Cancer 125:297-307(2009)

PubMed=23458625; DOI=10.1021/pr3010869
Susan Fanayan, Joshua T. Smith, Ling Y. Lee, Fang-Fei Yan, Michael P. Snyder, William S. Hancock, Edouard Nice;
Proteogenomic analysis of human colon carcinoma cell lines LIM1215, LIM1899, and LIM2405.
J. Proteome Res. 12:1732-1742(2013)

PubMed=24295106; DOI=10.1021/pr400861m
Manveen K. Sethi, Morten Thaysen-Andersen, Joshua T. Smith, Mark Scott Baker, Nicolle H. Packer, William S. Hancock, Susan Fanayan;
Comparative N-glycan profiling of colorectal cancer cell lines reveals unique bisecting GlcNAc and alpha-2,3-linked sialic acid determinants are associated with membrane proteins of the more metastatic/aggressive cell lines.
J. Proteome Res. 13:277-288(2014)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line collections (Providers) CBA; CBA-0163
ECACC; 12062001
Cell line databases/resources cancercelllines; CVCL_4435
ColonAtlas; LIM1899
Biological sample resources BioSample; SAMN07624414
Encyclopedic resources Wikidata; Q54902528
Gene expression databases GEO; GSM1346879
GEO; GSM1448136
GEO; GSM3145610
GEO; GSM3145716
Polymorphism and mutation databases Cosmic; 1238052
Cosmic; 1482517
Cosmic; 1486136
Cosmic; 1805259
Cosmic; 2301992
Proteomic databases PRIDE; PXD000120
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number33