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Cellosaurus NR8383 (CVCL_4396)

[Text version]
Cell line name NR8383
Synonyms NR-8383; NR 8383; NR8383.1; NR8383 clone AgCl1X3A; AgC11x3A; Normal Rat, August 3, 1983
Accession CVCL_4396
Resource Identification Initiative To cite this cell line use: NR8383 (RRID:CVCL_4396)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Provides a homogenous source of highly responsive alveolar macrophages which can be used in vitro to study macrophage related activities (ATCC=CRL-2192).
Anecdotal: Have been flown in space on the ISS in 2014-2015 to study growth and adaptation to microgravity (PubMed=28242876).
Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
Cell type: Alveolar macrophage; CL=CL_0000583.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley.
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/morphology-of-crl-2192

PubMed=3497918; DOI=10.1007/BF02620974
Helmke R.J., Boyd R.L., German V.F., Mangos J.A.
From growth factor dependence to growth factor responsiveness: the genesis of an alveolar macrophage cell line.
In Vitro Cell. Dev. Biol. 23:567-574(1987)

PubMed=2914814; DOI=10.1007/BF02624409
Helmke R.J., German V.F., Mangos J.A.
A continuous alveolar macrophage cell line: comparisons with freshly derived alveolar macrophages.
In Vitro Cell. Dev. Biol. 25:44-48(1989)

PubMed=9738661; DOI=10.1002/jlb.64.3.345
Lane K.B., Egan B., Vick S., Abdolrasulnia R., Shepherd V.L.
Characterization of a rat alveolar macrophage cell line that expresses a functional mannose receptor.
J. Leukoc. Biol. 64:345-350(1998)

PubMed=28242876; DOI=10.1038/s41598-017-00119-6
Thiel C.S., de Zelicourt D., Tauber S., Adrian A., Franz M., Simmet D.M., Schoppmann K., Hauschild S., Krammer S., Christen M., Bradacs G., Paulsen K., Wolf S.A., Braun M., Hatton J.P., Kurtcuoglu V., Franke S., Tanner S., Cristoforetti S., Sick B., Hock B., Ullrich O.
Rapid adaptation to microgravity in mammalian macrophage cells.
Sci. Rep. 7:43-43(2017)

Cell line collections (Providers) ATCC; CRL-2192
BCRC; 60423
CLS; 305200
KCB; KCB 2010189YJ
Cell line databases/resources CLO; CLO_0008193
CCRID; 1101RAT-PUMC000663
Lonza; 1390
Anatomy/cell type resources BTO; BTO:0002907
Encyclopedic resources Wikidata; Q54931021
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number22