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Cellosaurus NR8383 (CVCL_4396)

[Text version]
Cell line name NR8383
Synonyms NR-8383; NR 8383; NR8383.1; NR8383 clone AgCl1X3A; AgC11x3A; Normal Rat, August 3, 1983
Accession CVCL_4396
Resource Identification Initiative To cite this cell line use: NR8383 (RRID:CVCL_4396)
Comments Group: Space-flown cell line (cellonaut).
Characteristics: Provides a homogenous source of highly responsive alveolar macrophages which can be used in vitro to study macrophage related activities (ATCC=CRL-2192).
Anecdotal: Have been flown in space on the ISS in 2014-2015 to study growth and adaptation to microgravity (PubMed=28242876).
Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
Cell type: Alveolar macrophage; CL=CL_0000583.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS_0000681.
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/morphology-of-crl-2192
Publications

PubMed=3497918; DOI=10.1007/BF02620974
Ronald J. Helmke, R. Lee Boyd, Victor F. German, John A. Mangos;
From growth factor dependence to growth factor responsiveness: the genesis of an alveolar macrophage cell line.
In Vitro Cell. Dev. Biol. 23:567-574(1987)

PubMed=2914814; DOI=10.1007/BF02624409
Ronald J. Helmke, Victor F. German, John A. Mangos;
A continuous alveolar macrophage cell line: comparisons with freshly derived alveolar macrophages.
In Vitro Cell. Dev. Biol. 25:44-48(1989)

PubMed=9738661; DOI=10.1002/jlb.64.3.345
Kirk B. Lane, Brian Egan, Sherell Vick, Rasul Abdolrasulnia, Virginia L. Shepherd;
Characterization of a rat alveolar macrophage cell line that expresses a functional mannose receptor.
J. Leukoc. Biol. 64:345-350(1998)

PubMed=28242876; DOI=10.1038/s41598-017-00119-6; PMCID=PMC5427920
Cora Sandra Thiel, Diane de Zelicourt, Svantje Tauber, Astrid Adrian, Markus Franz, Dana Michaela Simmet, Kathrin Schoppmann, Swantje Hauschild, Sonja Krammer, Miriam Christen, Gesine Bradacs ...Show all 22 authors... , Katrin Paulsen, Susanne A. Wolf, Markus Braun, Jason P. Hatton, Vartan Kurtcuoglu, Stefanie Franke, Samuel Tanner, Samantha Cristoforetti, Beate Sick, Bertold Hock, Oliver Ullrich; Show fewer authors
Rapid adaptation to microgravity in mammalian macrophage cells.
Sci. Rep. 7:43-43(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-2192
BCRC; 60423
CLS; 305200
KCB; KCB 2010189YJ
Cell line databases/resources CLO; CLO_0008193
CCRID; 1101RAT-PUMC000663
CCRID; 3101RATGNR9
Lonza; 1390
Anatomy/cell type resources BTO; BTO_0002907
Encyclopedic resources Wikidata; Q54931021
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25