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Cellosaurus HBL-2 [Human mantle cell lymphoma] (CVCL_4216)

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Cell line name HBL-2 [Human mantle cell lymphoma]
Synonyms Hbl-2; HBL2
Accession CVCL_4216
Resource Identification Initiative To cite this cell line use: HBL-2 [Human mantle cell lymphoma] (RRID:CVCL_4216)
Comments Population: Japanese.
Doubling time: 36 hours (PubMed=3338018).
Karyotypic information: Has lost chromosome Y.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Cervical lymph node; UBERON=UBERON_0002429.
HLA typing Source: PubMed=25960936
Class I
HLA-AA*31:01,24:02
HLA-BB*52:01,35:01
HLA-CC*04:01,12:02
Class II
HLA-DQDQA1*03:02,01:03
DQB1*06:01,03:03
HLA-DRDRB1*09:01,15:02
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 84Y
Category Cancer cell line
Publications

PubMed=3338018; DOI=10.1002/1097-0142(19880201)61:3<483::AID-CNCR2820610313>3.0.CO;2-L
Masafumi Abe, Yoshihiro Nozawa, Haruki Wakasa, Hitoshi Ohno, Shiro Fukuhara;
Characterization and comparison of two newly established Epstein-Barr virus-negative lymphoma B-cell lines. Surface markers, growth characteristics, cytogenetics, and transplantability.
Cancer 61:483-490(1988)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15028022; DOI=10.1111/j.1440-1827.2004.01612.x
Katsuhito Kamimura, Hiroshi Hojo, Masafumi Abe;
Characterization of expression of protein kinase C isozymes in human B-cell lymphoma: relationship between its expression and prognosis.
Pathol. Int. 54:224-230(2004)

PubMed=16183118; DOI=10.1016/j.leukres.2005.08.016
Catherine A. Tucker, Gwyn Bebb, Richard J. Klasa, Mukesh Chhanabhai, Valia S. Lestou, Douglas E. Horsman, Randy D. Gascoyne, Adrian Wiestner, Dana Masin, Marcel Bally, Michael E. Williams;
Four human t(11;14)(q13;q32)-containing cell lines having classic and variant features of mantle cell lymphoma.
Leuk. Res. 30:449-457(2006)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald ...Show all 21 authors... , Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=17332242; DOI=10.1182/blood-2006-11-057208
Magda Pinyol, Silvia Bea, Laura Pla, Vincent Ribrag, Jacques Bosq, Andreas Rosenwald, Elias Campo, Pedro Jares;
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.
Blood 109:5422-5429(2007)

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731
Elena Beltran, Vicente Fresquet, Javier Martinez-Useros, Jose A. Richter-Larrea, Ainara Sagardoy, Izaskun Sesma, Luciana L. Almada, Santiago Montes-Moreno, Reiner Siebert, Stefan Gesk, Maria J. Calasanz ...Show all 18 authors... , Raquel Malumbres, Melissa Rieger, Felipe Prosper, Izidore S. Lossos, Miguel Angel Piris, Martin E. Fernandez-Zapico, Jose Angel Martinez-Climent; Show fewer authors
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=24362935; DOI=10.1038/nm.3435
Rami Rahal, Mareike Frick, Rodrigo Romero, Joshua M. Korn, Robert Kridel, Fong Chun Chan, Barbara Meissner, Hyo-eun Carrie Bhang, David A. Ruddy, Audrey Kauffmann, Ali Farsidjani ...Show all 30 authors... , Adnan Derti, Daniel Rakiec, Tara Naylor, Estelle Pfister, Steve Kovats, Sunkyu Kim, Kerstin Dietze, Bernd Dorken, Christian Steidl, Alexandar Tzankov, Michael Hummel, John E. Monahan, Michael P. Morrissey, Christine Fritsch, William Raj Sellers, Vesselina G. Cooke, Randy D. Gascoyne, Georg Lenz, Frank Stegmeier; Show fewer authors
Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.
Nat. Med. 20:87-92(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332
Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, De-Kuang Zhao, Xiao-Yu Jiang, Elif Isik, Anthony George Letai, Izidore S. Lossos;
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

Cross-references
Anatomy/cell type resources BTO; BTO_0002523
Encyclopedic resources Wikidata; Q54881432
Gene expression databases GEO; GSM155078
GEO; GSM155079
GEO; GSM155080
GEO; GSM629486
GEO; GSM629487
GEO; GSM1266775
GEO; GSM1266776
Polymorphism and mutation databases Cosmic; 1047112
Cosmic; 2296990
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number22