| Comments |
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: ~32 hours (PBCF).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; HLA class I peptidome.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
|---|
| Sequence variations |
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=9598804).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (PubMed=9598804; PubMed=17260012; PubMed=23851445; ATCC=HTB-65; DepMap=ACH-000987).
- Mutation; HGNC; HGNC:3688; FGFR1; Simple; p.Pro252Ser (c.754C>T); Zygosity=Unspecified (PubMed=23851445).
- Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (ATCC=HTB-65).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
|
|---|
| HLA typing |
Source: PubMed=15592718
| Class I | | HLA-A | A*02:01,26:01 | | HLA-B | B*14:02,38:01 | | HLA-C | C*08:02,12:03 | | Class II | | HLA-DP | DPB1*04:01,04:02 | | HLA-DQ | DQB1*03:01:01,05:01 | | HLA-DR | DRB1*11:01,01:02 |
Source: PubMed=25960936
| Class I | | HLA-A | A*02:01,26:01 |
Source: PubMed=26589293
| Class I | | HLA-A | A*02:01,26:01 | | HLA-B | B*14:02,67:02 | | HLA-C | C*12:03,12:03 | | Class II | | HLA-DQ | DQB1*06:13,06:13 | | HLA-DR | DRB1*11:30,14:17 |
|
|---|
| Genome ancestry |
Source: PubMed=30894373
| Origin | % genome |
|---|
|
| African | 2.39 | | Native American | 1.31 | | East Asian, North | 0.6 | | East Asian, South | 0.77 | | South Asian | 7.24 | | European, North | 25.84 | | European, South | 61.86 |
|
|---|
| Disease |
Cutaneous melanoma (NCIt: C3510) |
|---|
| Species of origin |
Mus musculus (Mouse)
(NCBI Taxonomy: 9606) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
78Y |
|---|
| Category |
Cancer cell line |
|---|
| STR profile |
Source(s): ATCC=HTB-65; CLS=300285; Cosmic-CLP=908128; ESTDAB=ESTDAB-050; JCRB=JCRB0066; PubMed=25877200; Technion Genomics Center
Markers:
Run an STR similarity search on this cell line |
|---|
| Web pages |
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544466
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-532.html |
|---|
| Publications |
Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
Cancer Cell 33:386-400.e5(2018)
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 48 |
|---|
