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Cellosaurus KOCL-69 (CVCL_3995)

[Text version]
Cell line name KOCL-69
Synonyms KOCL69
Accession CVCL_3995
Resource Identification Initiative To cite this cell line use: KOCL-69 (RRID:CVCL_3995)
Comments Population: Japanese.
Omics: Phenotyping; Drug screening.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling <1Y
Category Cancer cell line
Publications

PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912
Kazuhito Yamamoto, Masao Seto, Shinsuke Iida, Hirokazu Komatsu, Nanao Kamada, Seiji Kojima, Yoshihisa Kodera, Shinpei Nakazawa, Hidehiko Saito, Toshitada Takahashi, Ryuzo Ueda;
A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.
Blood 83:2912-2921(1994)

PubMed=9529133; DOI=10.1038/sj.leu.2400951
Takeshi Inukai, Kanji Sugita, Kumiko Iijima, Kumiko Goi, Toshiki Tezuka, Satoru Kojika, Keiko Kagami, Taijiro Mori, Akitoshi Kinoshita, Toshio Suzuki, Toshiko Koyama-Okazaki, Shinpei Nakazawa;
Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF.
Leukemia 12:382-389(1998)

PubMed=10360377; DOI=10.1038/sj.leu.2401437
Makoto Nakamura, Kanji Sugita, Takeshi Inukai, Kumiko Goi, Kumiko Iijima, Toshiki Tezuka, Satoru Kojika, Kenji Shiraishi, Nariaki Miyamoto, Naoko Karakida, Keiko Kagami ...Show all 14 authors... , Toshiko Koyama-Okazaki, T. Mori, Shinpei Nakazawa; Show fewer authors
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.
Leukemia 13:884-890(1999)

PubMed=10995006; DOI=10.1038/sj.leu.2401893
Kumiko Iijima, K. Sugita, T. Inukai, Kumiko Goi, Toshiki Tezuka, K. Uno, H. Sato, Keiko Kagami, Shinpei Nakazawa;
Expression of thrombopoietin receptor and its functional role in human B-precursor leukemia cells with 11q23 translocation or Philadelphia chromosome.
Leukemia 14:1598-1605(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Takeshi Taketani, Tomohiko Taki, Kanji Sugita, Yoshiyuki Furuichi, Eiichi Ishii, Ryoji Hanada, Masahiro Tsuchida, Kenichi Sugita, Kohmei Ida, Yasuhide Hayashi;
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Hans Gunther Drexler, Hilmar Quentmeier, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Kinuko Hirose, Takeshi Inukai, Jiro Kikuchi, Yusuke Furukawa, Tomokatsu Ikawa, Hiroshi Kawamoto, S. Helen Oram, Berthold Gottgens, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Hajime Okita ...Show all 22 authors... , Koshi Akahane, Xiao-Chun Zhang, Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Hidemitsu Kurosawa, Alfred Thomas Look, Hirotaka Matsui, Toshiya Inaba, Kanji Sugita; Show fewer authors
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Takeshi Inukai, Xiu-Ru Zhang, Takeshi Kameyama, Yukiko Suzuki, Kazuhito Yoshikawa, Itaru Kuroda, Atsushi Nemoto, Koshi Akahane, Hiroki Sato, Kumiko Goi, Kazunori Nakamoto ...Show all 15 authors... , Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Kanji Sugita; Show fewer authors
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=28569787; DOI=10.1038/cddis.2017.249; PMCID=PMC5520907
Shin Kasai, Yoshiyuki Furuichi, Norie Ando, Keiko Kagami, Masako Abe, Takaya Nakane, Kumiko Goi, Takeshi Inukai, Sei Saitoh, Shinichi Ohno, Shogo Okazaki ...Show all 14 authors... , Osamu Nagano, Hideyuki Saya, Kanji Sugita; Show fewer authors
Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.
Cell Death Dis. 8:e2857.1-e2857.11(2017)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=31305009; DOI=10.1002/cam4.2356; PMCID=PMC6718581
Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki ...Show all 29 authors... , Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark P. Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, Kanji Sugita; Show fewer authors
Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Cancer Med. 8:5274-5288(2019)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3995
Anatomy/cell type resources BTO; BTO_0004941
Encyclopedic resources Wikidata; Q54900285
Polymorphism and mutation databases Cosmic; 996299
Cosmic; 1037751
IARC_TP53; 28415
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number24