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Cellosaurus NCI-H1334 (CVCL_3971)

[Text version]
Cell line name NCI-H1334
Synonyms H1334; H-1334
Accession CVCL_3971
Resource Identification Initiative To cite this cell line use: NCI-H1334 (RRID:CVCL_3971)
Comments Problematic cell line: Probably contaminated. The STR profile is identical to that of the NCI-H322 cell line. Originally thought to originate from a 56 year old male patient with a large cell lung carcinoma.
Population: Caucasian.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Club cell; CL=CL_0000158.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu224Asp (c.672G>C); ClinVar=VCV001493447; Zygosity=Unspecified (PubMed=1311061).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1556 (NCI-H322)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-5863; PubMed=11416159

Markers:
AmelogeninX
CSF1PO12
D5S81811
D7S82011
D8S117912,15
D13S31712
D16S53911,12
D18S5117
D21S1128
FGA22
TH017
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2386953
Adi F. Gazdar, Ritva Ilona Linnoila, Yukio Kurita, Herbert Kazuto Oie, James L. Mulshine, Jean C. Clark, Jeffrey A. Whitsett;
Peripheral airway cell differentiation in human lung cancer cell lines.
Cancer Res. 50:5481-5487(1990)

PubMed=1311061
Tetsuya Mitsudomi, Seth M. Steinberg, Marion M. Nau, David P. Carbone, Domenico D'Amico, Sara M. Bodner, Herbert Kazuto Oie, Ritva Ilona Linnoila, James L. Mulshine, John D. Minna, Adi F. Gazdar;
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.
Oncogene 7:171-180(1992)

PubMed=8806092; DOI=10.1002/jcb.240630505
Ruby M. Phelps, Bruce E. Johnson, Daniel C. Ihde, Adi F. Gazdar, David P. Carbone, Patrick R. McClintock, Ritva Ilona Linnoila, Mary J. Matthews, Paul A. Bunn Jr., Desmond Niall Carney, John D. Minna, James L. Mulshine;
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Sanjay Modi, Akihito Kubo, Herbert Kazuto Oie, Amy B. Coxon, Ahad Rehmatulla, Frederic J. Kaye;
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
James L. Mulshine, Peter Ujhazy, Melissa Antman, Christine M. Burgess, Igor A. Kuzmin, Paul A. Bunn Jr., Bruce E. Johnson, Jack Alan Roth, Harvey I. Pass, Sheila M. Ross, Carolyn R. Aldige ...Show all 13 authors... , Ignacio Ivan Wistuba, John D. Minna; Show fewer authors
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-5863 - Discontinued
KCLB; 91334
Cell line databases/resources cancercelllines; CVCL_3971
Anatomy/cell type resources BTO; BTO_0003011
Encyclopedic resources Wikidata; Q54907791
Experimental variables resources EFO; EFO_0003117
Polymorphism and mutation databases Cosmic; 844596
Cosmic; 877419
Cosmic; 903586
Cosmic; 980972
Cosmic; 1032444
Cosmic; 1152509
Cosmic; 1891888
IARC_TP53; 488
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24