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Cellosaurus SNU-368 (CVCL_3948)

[Text version]
Cell line name SNU-368
Synonyms SNU368
Accession CVCL_3948
Resource Identification Initiative To cite this cell line use: SNU-368 (RRID:CVCL_3948)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 41 hours (PubMed=7543080); 42.77 hours (PubMed=31378681).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Genome sequenced.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11110; ARID1A; Simple; p.Leu1607Profs*41 (c.4817dupT); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; 903; AXIN1; Simple; p.Gln184Ter (c.550C>T); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser106Arg (c.318C>G); ClinVar=VCV000492752; Zygosity=Unspecified (PubMed=8824565; PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=31378681


Run an STR similarity search on this cell line
Web pages https://lccl.zucmanlab.com/hcc/cellLines/SNU368

PubMed=7543080; DOI=10.1002/ijc.2910620308
Park J.-G., Lee J.-H., Kang M.-S., Park K.-J., Jeon Y.-M., Lee H.-J., Kwon H.-S., Park H.-S., Yeo K.-S., Lee K.-U., Kim S.-T., Chung J.-K., Hwang Y.-J., Lee H.-S., Kim C.Y., Lee Y.I., Chen T.-R., Hay R.J., Song S.-Y., Kim W.-H., Ki C.-W., Kim Y.-I.
Characterization of cell lines established from human hepatocellular carcinoma.
Int. J. Cancer 62:276-282(1995)

PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X
Kang M.-S., Lee H.-J., Lee J.-H., Ku J.-L., Lee K.P., Kelley M.J., Won Y.-J., Kim S.-T., Park J.-G.
Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX DNA.
Int. J. Cancer 67:898-902(1996)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=16616112; DOI=10.1016/j.cancergencyto.2005.08.022
Park S.-J., Jeong S.-Y., Kim H.J.
Y chromosome loss and other genomic alterations in hepatocellular carcinoma cell lines analyzed by CGH and CGH array.
Cancer Genet. Cytogenet. 166:56-64(2006)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001
Qiu Z.-X., Li H., Zhang Z.-T., Zhu Z.-F., He S., Wang X.-J., Wang P.-C., Qin J.-J., Zhuang L.-P., Wang W., Xie F.-B., Gu Y., Zou K.-K., Li C., Li C., Wang C.-H., Cen J., Chen X.-T., Shu Y.-J., Zhang Z., Sun L.-L., Min L.-H., Fu Y., Huang X.-W., Lv H., Zhou H., Ji Y., Zhang Z.-G., Meng Z.-Q., Shi X.-L., Zhang H.-B., Li Y.-X., Hui L.-J.
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cell line collections (Providers) KCLB; 00368
Cell line databases/resources cancercelllines; CVCL_3948
Anatomy/cell type resources BTO; BTO:0003169
Encyclopedic resources Wikidata; Q54955179
Gene expression databases GEO; GSM1374889
GEO; GSM2551585
Polymorphism and mutation databases Cosmic; 2023866
IARC_TP53; 6305
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22