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Cellosaurus OVCAR-2 (CVCL_3941)

[Text version]
Cell line name OVCAR-2
Synonyms NIH:OVCAR-2; OVCAR2; OVCAR 2
Accession CVCL_3941
Resource Identification Initiative To cite this cell line use: OVCAR-2 (RRID:CVCL_3941)
Comments Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Ovarian carcinoma (NCIt: C4908)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6861 (Caov-2)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=22710073

Markers:
AmelogeninX
CSF1PO12
D2S133817,26
D3S135816
D5S81811
D7S82010
D8S117910,14
D13S31711
D16S53913
D18S5112,16
D19S43313
D21S1131
FGA22
TH019
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=6372095; DOI=10.1126/science.6372095
Alfred M. Rogan, Thomas C. Hamilton, Robert C. Young, Raymond W. Klecker Jr., Robert F. Ozols;
Reversal of adriamycin resistance by verapamil in human ovarian cancer.
Science 224:994-996(1984)

PubMed=6385258
Thomas C. Hamilton, Robert C. Young, Robert F. Ozols;
Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches.
Semin. Oncol. 11:285-298(1984)

PubMed=3930572; DOI=10.1172/JCI112082; PMCID=PMC424036
Robert Pirker, David J.P. FitzGerald, Thomas C. Hamilton, Robert F. Ozols, Walter Joseph Laird, Arthur Edward Frankel, Mark C. Willingham, Ira Pastan;
Characterization of immunotoxins active against ovarian cancer cell lines.
J. Clin. Invest. 76:1261-1267(1985)

PubMed=2307530; DOI=10.1002/ijc.2910450306
Russell J. Schilder, Lemuel Hall, Anne Monks, Laura M. Handel, Albert J. Fornace Jr., Robert F. Ozols, Antonio Fojo, Thomas C. Hamilton;
Metallothionein gene expression and resistance to cisplatin in human ovarian cancer.
Int. J. Cancer 45:416-422(1990)

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Andrew Kent Godwin, Alton Meister, Peter J. O'Dwyer, Chin-Shiou Huang, Thomas C. Hamilton, Mary E. Anderson;
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=9041185
Steven W. Johnson, Paul B. Laub, Jacqueline S. Beesley, Robert F. Ozols, Thomas C. Hamilton;
Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines.
Cancer Res. 57:850-856(1997)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3941
Anatomy/cell type resources BTO; BTO_0002560
Encyclopedic resources Wikidata; Q54937004
Gene expression databases GEO; GSM185133
GEO; GSM185134
GEO; GSM711707
GEO; GSM851933
GEO; GSM1340586
GEO; GSM1341131
Polymorphism and mutation databases Progenetix; CVCL_3941
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19