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Cellosaurus OVCAR-2 (CVCL_3941)

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Cell line name OVCAR-2
Synonyms NIH:OVCAR-2; OVCAR2; OVCAR 2
Accession CVCL_3941
Resource Identification Initiative To cite this cell line use: OVCAR-2 (RRID:CVCL_3941)
Comments Problematic cell line: Partially contaminated. Some stocks were contaminated by either Calu-6 or Caov-2 as identified by a STR profile (PubMed=22710073).
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Miscellaneous: STR profile from personal communication of Campbell, Kerry S. at Fox Chase Cancer Center. The stocks of OVCAR-2 used for profiling were obtained in 1982 from Hamilton, Thomas C. lab, where OVCAR-2 was established.
Caution: The STR profile reported by PubMed=22710073 was Amelogenin: X; CSF1PO: 12; D13S317: 11; D16S539: 13; D18S51: 12,16; D19S433: 13; D21S11: 31; D2S1338: 17,26; D3S1358: 16; D5S818: 11; D7S820: 10; D8S1179: 10,14; FGA: 22; TH01: 9; TPOX: 8; vWA: 17.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Ovarian carcinoma (NCIt: C4908)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO11,12
D3S135814,15
D5S81811,13
D7S8208,12
D8S11799,14
D13S3179,12
D16S53913
D18S5112
D21S1130,32.2
FGA20
Penta D8,9,13
Penta E13
TH018,9
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=6372095; DOI=10.1126/science.6372095
Alfred M. Rogan, Thomas C. Hamilton, Robert C. Young, Raymond W. Klecker Jr., Robert F. Ozols;
Reversal of adriamycin resistance by verapamil in human ovarian cancer.
Science 224:994-996(1984)

PubMed=6385258
Thomas C. Hamilton, Robert C. Young, Robert F. Ozols;
Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches.
Semin. Oncol. 11:285-298(1984)

PubMed=3930572; DOI=10.1172/JCI112082; PMCID=PMC424036
Robert Pirker, David J.P. FitzGerald, Thomas C. Hamilton, Robert F. Ozols, Walter Joseph Laird, Arthur Edward Frankel, Mark C. Willingham, Ira Pastan;
Characterization of immunotoxins active against ovarian cancer cell lines.
J. Clin. Invest. 76:1261-1267(1985)

PubMed=2307530; DOI=10.1002/ijc.2910450306
Russell J. Schilder, Lemuel Hall, Anne Monks, Laura M. Handel, Albert J. Fornace Jr., Robert F. Ozols, Antonio Fojo, Thomas C. Hamilton;
Metallothionein gene expression and resistance to cisplatin in human ovarian cancer.
Int. J. Cancer 45:416-422(1990)

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Andrew Kent Godwin, Alton Meister, Peter J. O'Dwyer, Chin-Shiou Huang, Thomas C. Hamilton, Mary E. Anderson;
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=9041185
Steven W. Johnson, Paul B. Laub, Jacqueline S. Beesley, Robert F. Ozols, Thomas C. Hamilton;
Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines.
Cancer Res. 57:850-856(1997)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique Ann Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_3941
Anatomy/cell type resources BTO; BTO_0002560
Encyclopedic resources Wikidata; Q54937004
Gene expression databases GEO; GSM185133
GEO; GSM185134
GEO; GSM711707
GEO; GSM851933
GEO; GSM1340586
GEO; GSM1341131
Polymorphism and mutation databases Progenetix; CVCL_3941
Entry history
Entry creation04-Apr-2012
Last entry update27-Nov-2025
Version number20